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- W2055521552 abstract "FSH acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis, we have treated gonadotrophin-deficient hypogonadal ( hpg ) mice with recombinant FSH and measured changes in testicular transcript levels using microarrays and real-time PCR 12, 24 and 72 h after the start of treatment. Approximately 400 transcripts were significantly altered at each time point by FSH treatment. At 12 h, there was a clear increase in the levels of a number of known Sertoli cell transcripts (e.g. Fabp5 , Lgals1 , Tesc , Scara5 , Aqp5 ). Additionally, levels of Leydig cell transcripts were also markedly increased (e.g. Ren1 , Cyp17a1 , Akr1b7 , Star , Nr4a1 ). This was associated with a small but significant rise in testosterone at 24 and 72 h. At 24 h, androgen-dependent Sertoli cell transcripts were up-regulated (e.g. Rhox5 , Drd4 , Spinlw1 , Tubb3 and Tsx ) and this trend continued up to 72 h. By contrast with the somatic cells, only five germ cell transcripts ( Dkkl1 , Hdc , Pou5f1 , Zfp541 and 1700021K02Rik ) were altered by FSH within the time-course of the experiment. Analysis of canonical pathways showed that FSH induced a general decline in transcripts related to formation and regulation of tight junctions. Results show that FSH acts directly and indirectly to induce rapid changes in Sertoli cell and Leydig cell transcript levels in the hpg mouse but that effects on germ cell development must occur over a longer time-span." @default.
- W2055521552 created "2016-06-24" @default.
- W2055521552 creator A5010470592 @default.
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- W2055521552 creator A5033871262 @default.
- W2055521552 creator A5042350005 @default.
- W2055521552 creator A5086571849 @default.
- W2055521552 date "2009-01-09" @default.
- W2055521552 modified "2023-10-12" @default.
- W2055521552 title "Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse" @default.
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- W2055521552 doi "https://doi.org/10.1677/jme-08-0107" @default.
- W2055521552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2659293" @default.
- W2055521552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19136570" @default.
- W2055521552 hasPublicationYear "2009" @default.
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