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- W2055526592 abstract "P1P6-di(adenosine-5′)hexaphosphate (Ap6A) has been recently demonstrated in mammalian cells, yet its function remains unknown. Using single-channel current recordings, we studied the effect of Ap6A on guinea-pig cardiac ATP-sensitive K+ (KATP) channels. When applied to the intracellular side of excised membrane patches, Ap6A produced a concentration-dependent inhibition (half-maximal inhibitory concentration: 14 μM; Hill coefficient: 1.1) of KATP channel activity. We conclude that Ap6A is a potent inhibitory ligand of KATP channels." @default.
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- W2055526592 date "1995-11-01" @default.
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- W2055526592 title "Diadenosine-hexaphosphate is an inhibitory ligand of myocardial ATP-sensitive K+ channels" @default.
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- W2055526592 doi "https://doi.org/10.1016/0014-2999(95)00611-n" @default.
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