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• W2055536761 abstract "DNA and poly A have been studied in solution by small-angle X-ray scattering techniques, as a function either of temperature (DNA) or of pH (poly A). The shape of the X-ray diffraction curves is first analysed in order to check if the conformation of the solute can be assumed to be rod-like; when this is the case, the mass per unit length μ and the axial radius of gyration Rc of the rods can be determined. DNA in saline. At room temperature DNA is rod-like, and μ and Rc are in excellent agreement with the Watson-Crick model. As the temperature is raised, the structure remains the same at first, then a change is observed: the rod-like configuration is apparently preserved, but μ and Rc decrease. DNA in saline containing formaldehyde. At room temperature the structure is the same as in the absence of formaldehyde. As the temperature is raised, the X-ray curves remain the same at first, then change over a fairly narrow range of temperature. Above this temperature the curves remain the same for 20 to 30°C: their shape is typical of rod-like particles, but μ ~ ½μ28°C. At a still higher temperature another transition takes place, after which the structure is not rod-like. DNA in glycol. At low temperatures (t < 10°C)the X-ray data are consistent with the Watson-Crick model. As the temperature is raised a transition is observed, after which the X-ray curves remain the same up to 120°C. In this region the structure appears to be rod-like, with μ ∼ ½μ10°c. At t > 125°C, a transition to a non-rod conformation is observed. Poly A. In the pH range from 5·0 to 7·2, the X-ray curves are typical of rods, but a transition takes place near pH 5·9. From pH 5·0 to 5·9, μ and Rc agree with the structure observed in oriented fibres. From pH 5·9 to 7·2, μ drops to a lower value, consistent with a linear density of one nucleotide per 3·4 Å. In order to explain these observations, it is necessary to postulate the existence of at least three different structures. The native form, consistent with the Watson-Crick model, the denatured form, probably a random coil, and an intermediate form. This last form is exhibited by DNA either in saline containing formaldehyde at moderate temperatures, or in glycol at high temperatures, and by poly A at neutral pH. The conformation of the intermediate form appears to be rod-like, with a linear density of one nucleotide per 3·4 Å and Rc ∼ 5·8 Å. Two structures are proposed that agree with these conditions. In both structures the base planes are stacked and perpendicular to the helix axis, and the specific hydrogen bonds linking the base pairs are broken." @default.
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• W2055536761 date "1964-10-01" @default.
• W2055536761 modified "2023-10-12" @default.
• W2055536761 title "Structure transitions observed in DNA and poly A in solution as a function of temperature and pH" @default.
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• W2055536761 doi "https://doi.org/10.1016/s0022-2836(64)80025-5" @default.
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