FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055542085> ?p ?o ?g. }

• W2055542085 endingPage "164" @default.
• W2055542085 startingPage "156" @default.
• W2055542085 abstract "Streptomyces griseolus cytochrome P450SU-1 (CYP105A1) was expressed in Escherichia coli at a level of 1.0 μmol/L culture and purified with a specific content of 18.0 nmol/mg protein. Enzymatic studies revealed that CYP105A1 had 25-hydroxylation activity towards vitamin D2 and vitamin D3. Surprisingly, CYP105A1 also showed 1α-hydroxylation activity towards 25(OH)D3. As mammalian mitochondrial CYP27A1 catalyzes a similar two-step hydroxylation towards vitamin D3, the enzymatic properties of CYP105A1 were compared with those of human CYP27A1. The major metabolite of vitamin D2 by CYP105A1 was 25(OH)D2, while the major metabolites by CYP27A1 were both 24(OH)D2 and 27(OH)D2. These results suggest that CYP105A1 recognizes both vitamin D2 and vitamin D3 in a similar manner, while CYP27A1 does not. The Km values of CYP105A1 for vitamin D2 25-hydroxylation, vitamin D3 25-hydroxylation, and 25-hydroxyvitamin D3 1α-hydroxylation were 0.59, 0.54, and 0.91 μM, respectively, suggesting a high affinity of CYP105A1 for these substrates." @default.
• W2055542085 created "2016-06-24" @default.
• W2055542085 creator A5026234281 @default.
• W2055542085 creator A5027935946 @default.
• W2055542085 creator A5036846494 @default.
• W2055542085 creator A5036897372 @default.
• W2055542085 creator A5050719229 @default.
• W2055542085 creator A5084752721 @default.
• W2055542085 creator A5085721249 @default.
• W2055542085 date "2004-07-01" @default.
• W2055542085 modified "2023-10-17" @default.
• W2055542085 title "Conversion of vitamin D3 to 1α,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1" @default.
• W2055542085 cites W1507465276 @default.
• W2055542085 cites W1532212858 @default.
• W2055542085 cites W1547482025 @default.
• W2055542085 cites W1548020831 @default.
• W2055542085 cites W1552750745 @default.
• W2055542085 cites W1554763469 @default.
• W2055542085 cites W1583665893 @default.
• W2055542085 cites W1584952486 @default.
• W2055542085 cites W1775749144 @default.
• W2055542085 cites W1968132781 @default.
• W2055542085 cites W1969609483 @default.
• W2055542085 cites W1970847421 @default.
• W2055542085 cites W1973216325 @default.
• W2055542085 cites W2000051743 @default.
• W2055542085 cites W2002090680 @default.
• W2055542085 cites W2002678890 @default.
• W2055542085 cites W2008585978 @default.
• W2055542085 cites W2010897322 @default.
• W2055542085 cites W2028164367 @default.
• W2055542085 cites W2036984750 @default.
• W2055542085 cites W2051639214 @default.
• W2055542085 cites W2057649508 @default.
• W2055542085 cites W2058308246 @default.
• W2055542085 cites W2061734069 @default.
• W2055542085 cites W2069014655 @default.
• W2055542085 cites W2069383163 @default.
• W2055542085 cites W2073710684 @default.
• W2055542085 cites W2086312371 @default.
• W2055542085 cites W2086823401 @default.
• W2055542085 cites W2092951411 @default.
• W2055542085 cites W2097614410 @default.
• W2055542085 cites W2106411950 @default.
• W2055542085 cites W2125937496 @default.
• W2055542085 cites W2142877486 @default.
• W2055542085 cites W2146883739 @default.
• W2055542085 cites W2157342715 @default.
• W2055542085 cites W2330768369 @default.
• W2055542085 cites W2406232976 @default.
• W2055542085 doi "https://doi.org/10.1016/j.bbrc.2004.05.140" @default.
• W2055542085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15207715" @default.
• W2055542085 hasPublicationYear "2004" @default.
• W2055542085 type Work @default.
• W2055542085 sameAs 2055542085 @default.
• W2055542085 citedByCount "57" @default.
• W2055542085 countsByYear W20555420852012 @default.
• W2055542085 countsByYear W20555420852013 @default.
• W2055542085 countsByYear W20555420852014 @default.
• W2055542085 countsByYear W20555420852015 @default.
• W2055542085 countsByYear W20555420852016 @default.
• W2055542085 countsByYear W20555420852017 @default.
• W2055542085 countsByYear W20555420852018 @default.
• W2055542085 countsByYear W20555420852019 @default.
• W2055542085 countsByYear W20555420852020 @default.
• W2055542085 countsByYear W20555420852021 @default.
• W2055542085 countsByYear W20555420852022 @default.
• W2055542085 countsByYear W20555420852023 @default.
• W2055542085 crossrefType "journal-article" @default.
• W2055542085 hasAuthorship W2055542085A5026234281 @default.
• W2055542085 hasAuthorship W2055542085A5027935946 @default.
• W2055542085 hasAuthorship W2055542085A5036846494 @default.
• W2055542085 hasAuthorship W2055542085A5036897372 @default.
• W2055542085 hasAuthorship W2055542085A5050719229 @default.
• W2055542085 hasAuthorship W2055542085A5084752721 @default.
• W2055542085 hasAuthorship W2055542085A5085721249 @default.
• W2055542085 hasConcept C124490489 @default.
• W2055542085 hasConcept C134018914 @default.
• W2055542085 hasConcept C181199279 @default.
• W2055542085 hasConcept C185592680 @default.
• W2055542085 hasConcept C2776940978 @default.
• W2055542085 hasConcept C2777477808 @default.
• W2055542085 hasConcept C2780106736 @default.
• W2055542085 hasConcept C2780768313 @default.
• W2055542085 hasConcept C2781109383 @default.
• W2055542085 hasConcept C526171541 @default.
• W2055542085 hasConcept C55493867 @default.
• W2055542085 hasConcept C7309524 @default.
• W2055542085 hasConcept C86803240 @default.
• W2055542085 hasConceptScore W2055542085C124490489 @default.
• W2055542085 hasConceptScore W2055542085C134018914 @default.
• W2055542085 hasConceptScore W2055542085C181199279 @default.
• W2055542085 hasConceptScore W2055542085C185592680 @default.
• W2055542085 hasConceptScore W2055542085C2776940978 @default.
• W2055542085 hasConceptScore W2055542085C2777477808 @default.
• W2055542085 hasConceptScore W2055542085C2780106736 @default.
• W2055542085 hasConceptScore W2055542085C2780768313 @default.
• W2055542085 hasConceptScore W2055542085C2781109383 @default.

• next