Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055542425> ?p ?o ?g. }
- W2055542425 endingPage "36" @default.
- W2055542425 startingPage "5" @default.
- W2055542425 abstract "The development of small molecules as effective neuropharmaceuticals requires that these compounds undergo significant transport through the brain capillary endothelial wall, which makes up the blood-brain barrier (BBB) in vivo. While it is often assumed that any small molecule undergoes passive diffusion through the BBB, the evidence in the literature suggests only small molecules that (a) are lipid-soluble and (b) have a molecular weight < 400-600 Da threshold, are transported through the BBB via lipid-mediation in pharmacologically significant amounts. Exceptions to this rule are lipid-soluble molecules with a molecular weight of < 400 Da that are actively bound by plasma proteins in vivo; and small molecules that are transported through the BBB via carrier-mediated transport. This paper reviews the biology of small molecule transport through the BBB, and also reviews the various methodologies available for assessing whether small molecules undergo significant transport through the BBB in vivo." @default.
- W2055542425 created "2016-06-24" @default.
- W2055542425 creator A5000308279 @default.
- W2055542425 date "1995-07-01" @default.
- W2055542425 modified "2023-10-02" @default.
- W2055542425 title "Transport of small molecules through the blood-brain barrier: biology and methodology" @default.
- W2055542425 cites W1174063724 @default.
- W2055542425 cites W121250620 @default.
- W2055542425 cites W1517459426 @default.
- W2055542425 cites W1534839923 @default.
- W2055542425 cites W1550381156 @default.
- W2055542425 cites W1558311166 @default.
- W2055542425 cites W1558889227 @default.
- W2055542425 cites W1599388734 @default.
- W2055542425 cites W1624721816 @default.
- W2055542425 cites W16603568 @default.
- W2055542425 cites W1853999417 @default.
- W2055542425 cites W1965786289 @default.
- W2055542425 cites W1969373596 @default.
- W2055542425 cites W1970349857 @default.
- W2055542425 cites W1971903700 @default.
- W2055542425 cites W1971932631 @default.
- W2055542425 cites W1974296046 @default.
- W2055542425 cites W1974500405 @default.
- W2055542425 cites W1976155297 @default.
- W2055542425 cites W1976695616 @default.
- W2055542425 cites W1977025244 @default.
- W2055542425 cites W1977470728 @default.
- W2055542425 cites W1979409628 @default.
- W2055542425 cites W1979887303 @default.
- W2055542425 cites W1981978560 @default.
- W2055542425 cites W1983202266 @default.
- W2055542425 cites W1983944507 @default.
- W2055542425 cites W1985259581 @default.
- W2055542425 cites W1991707478 @default.
- W2055542425 cites W1993565618 @default.
- W2055542425 cites W1995993817 @default.
- W2055542425 cites W1999061307 @default.
- W2055542425 cites W1999465707 @default.
- W2055542425 cites W2002082152 @default.
- W2055542425 cites W2002310136 @default.
- W2055542425 cites W2005993306 @default.
- W2055542425 cites W2009830651 @default.
- W2055542425 cites W2011886250 @default.
- W2055542425 cites W2011998352 @default.
- W2055542425 cites W2012473563 @default.
- W2055542425 cites W2012531784 @default.
- W2055542425 cites W2012799954 @default.
- W2055542425 cites W2013280216 @default.
- W2055542425 cites W2014133627 @default.
- W2055542425 cites W2015659645 @default.
- W2055542425 cites W2019231415 @default.
- W2055542425 cites W2020208565 @default.
- W2055542425 cites W2022528346 @default.
- W2055542425 cites W2025642274 @default.
- W2055542425 cites W2028560023 @default.
- W2055542425 cites W2032457217 @default.
- W2055542425 cites W2033485387 @default.
- W2055542425 cites W2034999905 @default.
- W2055542425 cites W2040488706 @default.
- W2055542425 cites W2042870108 @default.
- W2055542425 cites W2043804739 @default.
- W2055542425 cites W2044228427 @default.
- W2055542425 cites W2044352580 @default.
- W2055542425 cites W2051188685 @default.
- W2055542425 cites W2051509842 @default.
- W2055542425 cites W2055375115 @default.
- W2055542425 cites W2055718543 @default.
- W2055542425 cites W2060598255 @default.
- W2055542425 cites W2062486586 @default.
- W2055542425 cites W2063991043 @default.
- W2055542425 cites W2064812215 @default.
- W2055542425 cites W2065171962 @default.
- W2055542425 cites W2066110982 @default.
- W2055542425 cites W2066696403 @default.
- W2055542425 cites W2067223842 @default.
- W2055542425 cites W2067313876 @default.
- W2055542425 cites W2075524053 @default.
- W2055542425 cites W2078004577 @default.
- W2055542425 cites W2078079205 @default.
- W2055542425 cites W2081148102 @default.
- W2055542425 cites W2082007124 @default.
- W2055542425 cites W2085146964 @default.
- W2055542425 cites W2086399607 @default.
- W2055542425 cites W2086615709 @default.
- W2055542425 cites W2090282808 @default.
- W2055542425 cites W2090625720 @default.
- W2055542425 cites W2092675752 @default.
- W2055542425 cites W2105301861 @default.
- W2055542425 cites W2109322747 @default.
- W2055542425 cites W2112001901 @default.
- W2055542425 cites W2112219075 @default.
- W2055542425 cites W2125164441 @default.
- W2055542425 cites W2129228358 @default.
- W2055542425 cites W2129237305 @default.
- W2055542425 cites W2129449449 @default.
- W2055542425 cites W2129843133 @default.
- W2055542425 cites W2130694858 @default.