FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055542989> ?p ?o ?g. }

• W2055542989 endingPage "38" @default.
• W2055542989 startingPage "33" @default.
• W2055542989 abstract "The neuregulin-1 (NRG-1)/ErbB system has emerged as a cardioprotective system that becomes activated during myocardial stress, most convincingly shown in response to cardiotoxic chemotherapy. Direct evidence of increased ventricular ErbB receptor activity in heart failure unrelated to cardiotoxic drugs is, however, limited. We investigated changes in NRG-1 expression, ErbB receptor phosphorylation and downstream activation of intracellular ErbB targets during rapid pacing and progressive ventricular dysfunction in the dog. Heart failure was induced in dogs by 7 weeks of rapid pacing. Ventricular function was assessed by echocardiography. Messenger RNA expression was investigated in ventricular biopsies using quantitative PCR. Activation of NRG-1/ErbB signaling and of downstream targets was investigated using immunoprecipitation and/or Western blotting. Over the course of 7 weeks of pacing and ventricular dilatation, ventricular levels of NRG-1, but not of other ErbB4 ligands, and of ADAM19, a protease promoting NRG-1 release, progressively increased. In parallel, levels of activated ErbB2 and ErbB4, phosphorylated at tyrosine residues 877/1248 and 1284 respectively, became progressively higher. Similarly, levels of total and phosphorylated PI-3 kinase increased. Surprisingly, however, and in contrast with activation of downstream targets of ErbB receptors in normal hearts, Akt and ERK1/2, remained inactivated. This study shows that ventricular ErbB2 and ErbB4 receptors become activated during the development of pacing-induced heart failure, but that downstream signaling is, at least partly, abrogated. Abrogation of cardioprotective signaling after ErbB activation is an unanticipated phenomenon in the progression of heart failure with possibly major pathophysiological significance. The underlying mechanisms should be further elucidated." @default.
• W2055542989 created "2016-06-24" @default.
• W2055542989 creator A5003871726 @default.
• W2055542989 creator A5053455165 @default.
• W2055542989 creator A5054708047 @default.
• W2055542989 creator A5062791325 @default.
• W2055542989 creator A5068670030 @default.
• W2055542989 creator A5069384969 @default.
• W2055542989 date "2009-01-01" @default.
• W2055542989 modified "2023-09-25" @default.
• W2055542989 title "Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure" @default.
• W2055542989 cites W1978030865 @default.
• W2055542989 cites W1978752343 @default.
• W2055542989 cites W1983530651 @default.
• W2055542989 cites W1987196222 @default.
• W2055542989 cites W1995527759 @default.
• W2055542989 cites W1996817878 @default.
• W2055542989 cites W2005675562 @default.
• W2055542989 cites W2036740994 @default.
• W2055542989 cites W2045570557 @default.
• W2055542989 cites W2050674912 @default.
• W2055542989 cites W2051449338 @default.
• W2055542989 cites W2080330276 @default.
• W2055542989 cites W2094661839 @default.
• W2055542989 cites W2116120611 @default.
• W2055542989 cites W2125947965 @default.
• W2055542989 cites W2127115922 @default.
• W2055542989 cites W2142681531 @default.
• W2055542989 cites W2142826108 @default.
• W2055542989 cites W2144099695 @default.
• W2055542989 cites W2147506318 @default.
• W2055542989 cites W2153709908 @default.
• W2055542989 cites W2159845849 @default.
• W2055542989 cites W2162818956 @default.
• W2055542989 cites W2163786192 @default.
• W2055542989 cites W2170016411 @default.
• W2055542989 cites W2171952998 @default.
• W2055542989 cites W4239462698 @default.
• W2055542989 doi "https://doi.org/10.1016/j.yjmcc.2008.10.010" @default.
• W2055542989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19010331" @default.
• W2055542989 hasPublicationYear "2009" @default.
• W2055542989 type Work @default.
• W2055542989 sameAs 2055542989 @default.
• W2055542989 citedByCount "31" @default.
• W2055542989 countsByYear W20555429892012 @default.
• W2055542989 countsByYear W20555429892013 @default.
• W2055542989 countsByYear W20555429892014 @default.
• W2055542989 countsByYear W20555429892015 @default.
• W2055542989 countsByYear W20555429892016 @default.
• W2055542989 countsByYear W20555429892018 @default.
• W2055542989 countsByYear W20555429892019 @default.
• W2055542989 countsByYear W20555429892020 @default.
• W2055542989 countsByYear W20555429892021 @default.
• W2055542989 countsByYear W20555429892022 @default.
• W2055542989 crossrefType "journal-article" @default.
• W2055542989 hasAuthorship W2055542989A5003871726 @default.
• W2055542989 hasAuthorship W2055542989A5053455165 @default.
• W2055542989 hasAuthorship W2055542989A5054708047 @default.
• W2055542989 hasAuthorship W2055542989A5062791325 @default.
• W2055542989 hasAuthorship W2055542989A5068670030 @default.
• W2055542989 hasAuthorship W2055542989A5069384969 @default.
• W2055542989 hasConcept C101544691 @default.
• W2055542989 hasConcept C11960822 @default.
• W2055542989 hasConcept C126322002 @default.
• W2055542989 hasConcept C134018914 @default.
• W2055542989 hasConcept C170493617 @default.
• W2055542989 hasConcept C2778198053 @default.
• W2055542989 hasConcept C2778560701 @default.
• W2055542989 hasConcept C2779251935 @default.
• W2055542989 hasConcept C2780943970 @default.
• W2055542989 hasConcept C502942594 @default.
• W2055542989 hasConcept C62478195 @default.
• W2055542989 hasConcept C71924100 @default.
• W2055542989 hasConcept C75217442 @default.
• W2055542989 hasConcept C86803240 @default.
• W2055542989 hasConcept C95444343 @default.
• W2055542989 hasConceptScore W2055542989C101544691 @default.
• W2055542989 hasConceptScore W2055542989C11960822 @default.
• W2055542989 hasConceptScore W2055542989C126322002 @default.
• W2055542989 hasConceptScore W2055542989C134018914 @default.
• W2055542989 hasConceptScore W2055542989C170493617 @default.
• W2055542989 hasConceptScore W2055542989C2778198053 @default.
• W2055542989 hasConceptScore W2055542989C2778560701 @default.
• W2055542989 hasConceptScore W2055542989C2779251935 @default.
• W2055542989 hasConceptScore W2055542989C2780943970 @default.
• W2055542989 hasConceptScore W2055542989C502942594 @default.
• W2055542989 hasConceptScore W2055542989C62478195 @default.
• W2055542989 hasConceptScore W2055542989C71924100 @default.
• W2055542989 hasConceptScore W2055542989C75217442 @default.
• W2055542989 hasConceptScore W2055542989C86803240 @default.
• W2055542989 hasConceptScore W2055542989C95444343 @default.
• W2055542989 hasIssue "1" @default.
• W2055542989 hasLocation W20555429891 @default.
• W2055542989 hasLocation W20555429892 @default.
• W2055542989 hasOpenAccess W2055542989 @default.
• W2055542989 hasPrimaryLocation W20555429891 @default.
• W2055542989 hasRelatedWork W1482123580 @default.
• W2055542989 hasRelatedWork W1970439470 @default.

• next