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- W2055546367 abstract "The superior colliculus (SC) is a midbrain structure that plays a central role in the integration of information from different sensory modalities and the generation of orienting responses. Its normal function is thought to be governed by a strictly held balance between excitation and inhibition. This hypothesis was tested by recording from the same single units in the SC of cats before the injection of anesthetics, while anesthetics took effect, and after the injections during recovery. Sodium pentobarbital and ketamine, two agents commonly used in sensory physiology, were used. The results show a plethora of dose-dependent and nonlinear effects: the magnitude of evoked responses, receptive field properties, first spike latency, and bimodal integration were affected by both anesthetics in all units tested. Notably, prominent facilitation was observed at low levels of anesthesia, and inhibitory responses were changed into excitatory. Overall, the results challenge a fundamental tenet of sensory physiology: anesthesia, while decreasing single-unit responsiveness, leaves unaltered basic physiological properties." @default.
- W2055546367 created "2016-06-24" @default.
- W2055546367 creator A5036571520 @default.
- W2055546367 date "2005-06-22" @default.
- W2055546367 modified "2023-10-15" @default.
- W2055546367 title "Anesthetics Change the Excitation/Inhibition Balance That Governs Sensory Processing in the Cat Superior Colliculus" @default.
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- W2055546367 doi "https://doi.org/10.1523/jneurosci.1147-05.2005" @default.
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