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- W2055570976 abstract "The mammalian rod synapse transmits a binary signal (one photon or none) using tonic, rapid exocytosis. We constructed a quantitative, physical model of the synapse. Presynaptically, a single, linear active zone provides docking sites for approximately 130 vesicles, and a ribbon anchored to the active zone provides a depot for approximately 640 vesicles. Postsynaptically, 4 processes invaginate the terminal: 2 (known to have low affinity glutamate receptors) lie near the active zone (16 nm), and 2 (known to have high affinity glutamate receptors) lie at a distance (130-640 nm). The presynaptic structure seems designed to minimize fluctuations in tonic rate owing to empty docking sites, whereas the postsynaptic geometry may permit 1 vesicle to evoke an all-or-none response at all 4 postsynaptic processes." @default.
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- W2055570976 date "1995-03-01" @default.
- W2055570976 modified "2023-09-26" @default.
- W2055570976 title "Mammalian rod terminal: Architecture of a binary synapse" @default.
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- W2055570976 doi "https://doi.org/10.1016/0896-6273(95)90312-7" @default.
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