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- W2055571804 abstract "Study Objective To describe the institutional experience of plerixafor plus filgrastim as the initial peripheral blood stem cell (PBSC) mobilization (first-line strategy) and as rescue therapy after failure with filgrastim plus cyclophosphamide (second-line strategy). Design Retrospective medical record review. Setting Academic medical center. Patients Thirty-three patients (median age 62 yrs) who received plerixafor between January 2008 and December 2009. Measurements and Main Results We collected data on total CD34+ cell yield and number of apheresis sessions in both first-line and second-line plerixafor recipients. Mobilization with plerixafor plus filgrastim resulted in a median yield of 8.95 × 106 and 2.45 × 106 CD34+ cells/kg in patients with multiple myeloma or non-Hodgkin's lymphoma, respectively. As rescue mobilization, plerixafor plus filgrastim successfully mobilized CD34+ cells in 16 (84%) of 19 patients. When comparing first-line plerixafor plus filgrastim therapy with second-line therapy, we found an increase in CD34+ yield and 1 less apheresis day in patients with multiple myeloma, but no difference in patients with non-Hodgkin's lymphoma. Conclusion A regimen of plerixafor plus filgrastim successfully mobilized CD34+ cells in a median of 1 apheresis day for patients with multiple myeloma and 2 apheresis days for patients with non-Hodgkin's lymphoma, including patients who failed initial filgrastim plus cyclophosphamide mobilization. Plerixafor plus filgrastim could be a viable first-line option in patients with multiple myeloma, as it improved CD34+ cell yield and decreased number of apheresis days compared with second-line plerixafor plus filgrastim therapy, whereas it was comparable to second-line therapy in patients with non-Hodgkin's lymphoma." @default.
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- W2055571804 date "2012-07-01" @default.
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- W2055571804 title "Plerixafor as First- and Second-Line Strategies for Autologous Stem Cell Mobilization in Patients with Non-Hodgkin's Lymphoma or Multiple Myeloma" @default.
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- W2055571804 doi "https://doi.org/10.1002/j.1875-9114.2012.01096.x" @default.
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