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- W2055573618 abstract "Surface molecules such as HLA class 1, HLA-DR, intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-3 (LFA-3) on tumor cells play an important role in the immune system of cancer-bearing hosts. Interferon (IFN) gamma has been reported to have a variety of effects on cancer and immune cells. Specimens from gastric cancer (GC), colorectal cancer (CRC), and hepatocellular carcinoma (HCC) were studied. IFN gamma were locally administered into the tumors of some patients before surgical resection and the IFN gamma-treated groups were compared with the untreated groups. There was no expression of ICAM-1 by untreated HCC tumor cells, while, 75% of treated HCC tumor cells showed ICAM-1 expression. LFA-3 expression on cancer cells was increased by IFN gamma in CRC and HCC. The percentage of tumor-infiltrating lymphocytes (TIL) expressing CD3 and CD8 was higher in the IFN gamma-treated group than in the untreated control group in all these diseases. These findings suggest that host defense mechanisms were induced by preoperative intratumoral injection of IFN gamma and this change may result in better local control." @default.
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- W2055573618 date "1997-01-01" @default.
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- W2055573618 title "Increased expression of HLA and adhesion molecules, and increase of CD3(+), CD8(+) tumor-infiltrating lymphocytes after administration of interferon gamma in patients with gastrointestinal cancer" @default.
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- W2055573618 doi "https://doi.org/10.4993/acrt1992.6.21" @default.
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