FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055578595> ?p ?o ?g. }

• W2055578595 endingPage "196" @default.
• W2055578595 startingPage "183" @default.
• W2055578595 abstract "T-cell scanning for antigen-presenting cells (APC) is a finely tuned process. Whereas non-cognate APC trigger T-cell motility via chemokines and intercellular adhesion molecule-1 (ICAM-1), cognate APC deliver a stop signal resulting from antigen recognition. We tested in vitro the contribution of the actin cytoskeleton regulator Wiskott-Aldrich syndrome protein (WASP) to the scanning activity of primary human CD4(+) T cells. WASP knock-down resulted in increased T-cell motility upon encounter with non-cognate dendritic cells or B cells and reduced capacity to stop following antigen recognition. The high motility of WASP-deficient T cells was accompanied by a diminished ability to round up and to stabilize pauses. WASP-deficient T cells migrated in a normal proportion towards CXCL12, CCL19 and CCL21, but displayed an increased adhesion and elongation on ICAM-1. The elongated morphology of WASP-deficient T cells was related to a reduced confinement of high-affinity lymphocyte function-associated antigen 1 to the mid-cell zone. Our data therefore indicate that WASP controls CD4(+) T-cell motility upon APC encounter by regulating lymphocyte function-associated antigen 1 spatial distribution." @default.
• W2055578595 created "2016-06-24" @default.
• W2055578595 creator A5010488274 @default.
• W2055578595 creator A5016831792 @default.
• W2055578595 creator A5042010611 @default.
• W2055578595 creator A5055827548 @default.
• W2055578595 creator A5057628003 @default.
• W2055578595 creator A5091826371 @default.
• W2055578595 date "2012-09-04" @default.
• W2055578595 modified "2023-10-14" @default.
• W2055578595 title "Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1" @default.
• W2055578595 cites W1500654688 @default.
• W2055578595 cites W1518539840 @default.
• W2055578595 cites W1562441478 @default.
• W2055578595 cites W1576136791 @default.
• W2055578595 cites W1900620157 @default.
• W2055578595 cites W1977513008 @default.
• W2055578595 cites W2003812908 @default.
• W2055578595 cites W2011562061 @default.
• W2055578595 cites W2014304617 @default.
• W2055578595 cites W2023827249 @default.
• W2055578595 cites W2024957425 @default.
• W2055578595 cites W2026886673 @default.
• W2055578595 cites W2030549554 @default.
• W2055578595 cites W2033042234 @default.
• W2055578595 cites W2036763905 @default.
• W2055578595 cites W2049398130 @default.
• W2055578595 cites W2053508150 @default.
• W2055578595 cites W2062478481 @default.
• W2055578595 cites W2065514217 @default.
• W2055578595 cites W2072522584 @default.
• W2055578595 cites W2075787203 @default.
• W2055578595 cites W2076171916 @default.
• W2055578595 cites W2082818616 @default.
• W2055578595 cites W2088355509 @default.
• W2055578595 cites W2092668505 @default.
• W2055578595 cites W2096234619 @default.
• W2055578595 cites W2111248076 @default.
• W2055578595 cites W2116178189 @default.
• W2055578595 cites W2124478712 @default.
• W2055578595 cites W2124497742 @default.
• W2055578595 cites W2139743591 @default.
• W2055578595 cites W2141877778 @default.
• W2055578595 cites W2142214654 @default.
• W2055578595 cites W2158421588 @default.
• W2055578595 cites W2166759276 @default.
• W2055578595 cites W2170543497 @default.
• W2055578595 cites W2170831273 @default.
• W2055578595 cites W2324058233 @default.
• W2055578595 cites W2063487043 @default.
• W2055578595 doi "https://doi.org/10.1111/j.1365-2567.2012.03620.x" @default.
• W2055578595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3461399" @default.
• W2055578595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22804504" @default.
• W2055578595 hasPublicationYear "2012" @default.
• W2055578595 type Work @default.
• W2055578595 sameAs 2055578595 @default.
• W2055578595 citedByCount "20" @default.
• W2055578595 countsByYear W20555785952013 @default.
• W2055578595 countsByYear W20555785952014 @default.
• W2055578595 countsByYear W20555785952015 @default.
• W2055578595 countsByYear W20555785952018 @default.
• W2055578595 countsByYear W20555785952019 @default.
• W2055578595 countsByYear W20555785952020 @default.
• W2055578595 countsByYear W20555785952021 @default.
• W2055578595 countsByYear W20555785952022 @default.
• W2055578595 countsByYear W20555785952023 @default.
• W2055578595 crossrefType "journal-article" @default.
• W2055578595 hasAuthorship W2055578595A5010488274 @default.
• W2055578595 hasAuthorship W2055578595A5016831792 @default.
• W2055578595 hasAuthorship W2055578595A5042010611 @default.
• W2055578595 hasAuthorship W2055578595A5055827548 @default.
• W2055578595 hasAuthorship W2055578595A5057628003 @default.
• W2055578595 hasAuthorship W2055578595A5091826371 @default.
• W2055578595 hasBestOaLocation W20555785954 @default.
• W2055578595 hasConcept C142669718 @default.
• W2055578595 hasConcept C147483822 @default.
• W2055578595 hasConcept C1491633281 @default.
• W2055578595 hasConcept C153911025 @default.
• W2055578595 hasConcept C16224149 @default.
• W2055578595 hasConcept C203014093 @default.
• W2055578595 hasConcept C2776090121 @default.
• W2055578595 hasConcept C2780939953 @default.
• W2055578595 hasConcept C2993400109 @default.
• W2055578595 hasConcept C55493867 @default.
• W2055578595 hasConcept C58207958 @default.
• W2055578595 hasConcept C67662055 @default.
• W2055578595 hasConcept C85789140 @default.
• W2055578595 hasConcept C86803240 @default.
• W2055578595 hasConcept C8891405 @default.
• W2055578595 hasConcept C95444343 @default.
• W2055578595 hasConceptScore W2055578595C142669718 @default.
• W2055578595 hasConceptScore W2055578595C147483822 @default.
• W2055578595 hasConceptScore W2055578595C1491633281 @default.
• W2055578595 hasConceptScore W2055578595C153911025 @default.
• W2055578595 hasConceptScore W2055578595C16224149 @default.
• W2055578595 hasConceptScore W2055578595C203014093 @default.
• W2055578595 hasConceptScore W2055578595C2776090121 @default.
• W2055578595 hasConceptScore W2055578595C2780939953 @default.

• next