FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055604490> ?p ?o ?g. }

• W2055604490 endingPage "2395" @default.
• W2055604490 startingPage "2389" @default.
• W2055604490 abstract "Background Thrombin plays an important role in the pathogenesis of acute coronary thrombosis. We studied the effects of a direct thrombin inhibitor, recombinant desulfatohirudin, and heparin on plasma levels (at 0, 4, 12, and 24 hours) of fibrinopeptide A (FPA), which reflects thrombin action, and prothrombin fragment F1.2, which reflects thrombin generation, in patients with unstable angina. Methods and Results Patients were randomized to one of two doses of heparin (n=50) (target activated partial thromboplastin time, 65 to 90 seconds or 90 to 110 seconds) or one of four doses of r-hirudin (n=113) (0.05, 0.10, 0.20, or 0.30 mg·kg −1 ·h −1 by infusion). r-Hirudin induced a dose-dependent decline in plasma FPA. At 24 hours, FPA levels with 0.1- to 0.3-mg·kg −1 ·h −1 r-hirudin regimens were significantly lower than with 0.05 mg·kg −1 ·h −1 r-hirudin; levels with 0.1- to 0.2-mg·kg −1 ·h −1 r-hirudin regimens were lower than with both heparin regimens. Plasma F1.2 did not decline significantly during therapy with heparin or hirudin except at 0.3 mg·kg −1 ·h −1 hirudin. At 24 hours, they were higher with the 0.05-mg·kg −1 ·h −1 r-hirudin regimen than with other regimens. For comparable levels of thrombin generation (F1.2 levels), FPA levels were higher in heparin patients than in hirudin patients. For the same FPA values, the corresponding F1.2 values were higher in the hirudin group. Conclusions Our findings provide evidence for distinct in vivo effects of the two agents and suggest that r-hirudin is a relatively more potent inhibitor of thrombin action but a less effective inhibitor of thrombin generation than heparin. The lower FPA levels in hirudin patients may reflect its ability to inactivate clot-bound thrombin. The relative clinical efficacies of the two agents need to be defined by clinical trials in progress." @default.
• W2055604490 created "2016-06-24" @default.
• W2055604490 creator A5001806316 @default.
• W2055604490 creator A5033933251 @default.
• W2055604490 creator A5038621482 @default.
• W2055604490 creator A5053059102 @default.
• W2055604490 creator A5060370891 @default.
• W2055604490 creator A5061115846 @default.
• W2055604490 creator A5071249249 @default.
• W2055604490 creator A5084515381 @default.
• W2055604490 creator A5088903937 @default.
• W2055604490 date "1996-11-15" @default.
• W2055604490 modified "2023-09-25" @default.
• W2055604490 title "Distinct Effects of Recombinant Desulfatohirudin (Revasc) and Heparin on Plasma Levels of Fibrinopeptide A and Prothrombin Fragment F1.2 in Unstable Angina" @default.
• W2055604490 cites W143004001 @default.
• W2055604490 cites W1519085965 @default.
• W2055604490 cites W1792897501 @default.
• W2055604490 cites W1855915925 @default.
• W2055604490 cites W1891400877 @default.
• W2055604490 cites W1963913381 @default.
• W2055604490 cites W1966733064 @default.
• W2055604490 cites W1968797532 @default.
• W2055604490 cites W1972999624 @default.
• W2055604490 cites W2013547341 @default.
• W2055604490 cites W2023791250 @default.
• W2055604490 cites W2030145547 @default.
• W2055604490 cites W2032781826 @default.
• W2055604490 cites W2064383343 @default.
• W2055604490 cites W2071569782 @default.
• W2055604490 cites W2085223950 @default.
• W2055604490 cites W2138849164 @default.
• W2055604490 cites W2158424272 @default.
• W2055604490 cites W2159162837 @default.
• W2055604490 cites W2411137265 @default.
• W2055604490 cites W2413674647 @default.
• W2055604490 cites W2414845940 @default.
• W2055604490 cites W2417899551 @default.
• W2055604490 cites W2433173101 @default.
• W2055604490 cites W2526077258 @default.
• W2055604490 cites W4205210034 @default.
• W2055604490 cites W49038133 @default.
• W2055604490 doi "https://doi.org/10.1161/01.cir.94.10.2389" @default.
• W2055604490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8921778" @default.
• W2055604490 hasPublicationYear "1996" @default.
• W2055604490 type Work @default.
• W2055604490 sameAs 2055604490 @default.
• W2055604490 citedByCount "33" @default.
• W2055604490 countsByYear W20556044902012 @default.
• W2055604490 countsByYear W20556044902013 @default.
• W2055604490 crossrefType "journal-article" @default.
• W2055604490 hasAuthorship W2055604490A5001806316 @default.
• W2055604490 hasAuthorship W2055604490A5033933251 @default.
• W2055604490 hasAuthorship W2055604490A5038621482 @default.
• W2055604490 hasAuthorship W2055604490A5053059102 @default.
• W2055604490 hasAuthorship W2055604490A5060370891 @default.
• W2055604490 hasAuthorship W2055604490A5061115846 @default.
• W2055604490 hasAuthorship W2055604490A5071249249 @default.
• W2055604490 hasAuthorship W2055604490A5084515381 @default.
• W2055604490 hasAuthorship W2055604490A5088903937 @default.
• W2055604490 hasConcept C126322002 @default.
• W2055604490 hasConcept C144594695 @default.
• W2055604490 hasConcept C2777292125 @default.
• W2055604490 hasConcept C2777557582 @default.
• W2055604490 hasConcept C2777785093 @default.
• W2055604490 hasConcept C2778205648 @default.
• W2055604490 hasConcept C2778261982 @default.
• W2055604490 hasConcept C2778271848 @default.
• W2055604490 hasConcept C2778382381 @default.
• W2055604490 hasConcept C42219234 @default.
• W2055604490 hasConcept C500558357 @default.
• W2055604490 hasConcept C57002609 @default.
• W2055604490 hasConcept C71924100 @default.
• W2055604490 hasConcept C89560881 @default.
• W2055604490 hasConcept C98274493 @default.
• W2055604490 hasConceptScore W2055604490C126322002 @default.
• W2055604490 hasConceptScore W2055604490C144594695 @default.
• W2055604490 hasConceptScore W2055604490C2777292125 @default.
• W2055604490 hasConceptScore W2055604490C2777557582 @default.
• W2055604490 hasConceptScore W2055604490C2777785093 @default.
• W2055604490 hasConceptScore W2055604490C2778205648 @default.
• W2055604490 hasConceptScore W2055604490C2778261982 @default.
• W2055604490 hasConceptScore W2055604490C2778271848 @default.
• W2055604490 hasConceptScore W2055604490C2778382381 @default.
• W2055604490 hasConceptScore W2055604490C42219234 @default.
• W2055604490 hasConceptScore W2055604490C500558357 @default.
• W2055604490 hasConceptScore W2055604490C57002609 @default.
• W2055604490 hasConceptScore W2055604490C71924100 @default.
• W2055604490 hasConceptScore W2055604490C89560881 @default.
• W2055604490 hasConceptScore W2055604490C98274493 @default.
• W2055604490 hasIssue "10" @default.
• W2055604490 hasLocation W20556044901 @default.
• W2055604490 hasLocation W20556044902 @default.
• W2055604490 hasOpenAccess W2055604490 @default.
• W2055604490 hasPrimaryLocation W20556044901 @default.
• W2055604490 hasRelatedWork W2035336137 @default.
• W2055604490 hasRelatedWork W204612893 @default.
• W2055604490 hasRelatedWork W2055604490 @default.
• W2055604490 hasRelatedWork W2069352741 @default.

• next