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• W2055606644 endingPage "1979" @default.
• W2055606644 startingPage "1976" @default.
• W2055606644 abstract "<b><i>Background:</i></b> Copolymer 1 (Cop-1) is a random synthetic amino acid copolymer, effective in the treatment of the relapsing-remitting form of MS (RRMS). In vitro and in vivo studies suggest that the mechanism of Cop-1 involves its binding to major histocompatibility complex class II molecules as an initial step. <b><i>Objective:</i></b> To assess a possible relationship between human leukocyte antigen (HLA) alleles and response to Cop-1 therapy. <b><i>Methods:</i></b> Eighty-three patients with RRMS, 44 treated with Cop-1 and 39 with interferon β-1a (IFNβ-1a) for 2 years, were typed by molecular methods for HLA class II genes and subgrouped according to clinical outcome. <b><i>Results:</i></b> Data have shown a possible positive correlation between presence of DRB1*1501 and response to Cop-1 therapy (<i>p</i> = 0.008). No relationship between HLA alleles and therapy has been found in IFNβ-1a treated patients. <b><i>Conclusions:</i></b> Results suggest that DRB1*1501 might be relevant for the clinical outcome in Cop-1 treated patients and, if confirmed in larger studies, it could be helpful in the selection of RRMS patients for different therapeutic options." @default.
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• W2055606644 date "2001-12-11" @default.
• W2055606644 modified "2023-10-13" @default.
• W2055606644 title "HLA-DRB1*1501 and response to copolymer-1 therapy in relapsing-remitting multiple sclerosis" @default.
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• W2055606644 doi "https://doi.org/10.1212/wnl.57.11.1976" @default.
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