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- W2055607329 abstract "SUMMARY Developments in predictive molecular testing and personalized therapy of lung cancer have recently called for a major change in the histological and cytological activity requiring the pathologist to strictly connect with pulmonologists, oncologists and molecular biologists to improve patient management. Different clinical trials established that tyrosine kinase inhibitor therapy is superior to chemotherapy, when patients harbor EGFR mutations. Similarly, the patients whose lung carcinoma carries ALK fusion genes consistently respond to ALK inhibitors. These improvements have led to the understanding that the morphological diagnosis of lung adenocarcinoma requires a multidisciplinary approach; even more recently the College of American Pathologists, the International Association for the Study of Lung Cancer and the Association for Molecular Pathology encouraged to develop international guidelines for lung cancer biomarker testing. This paper summarizes the practical impact of these guidelines, focusing on the pathologist's role in daily EGFR testing practice." @default.
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- W2055607329 date "2015-04-01" @default.
- W2055607329 modified "2023-09-27" @default.
- W2055607329 title "EGFR testing and the CAP/IASLC/AMP lung cancer biomarker testing guidelines: knowledge gaps and future directions" @default.
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- W2055607329 doi "https://doi.org/10.2217/lmt.15.4" @default.
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