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• W2055608506 abstract "Summary Besides the two nuclear oestrogen receptors ( ESR 1/ ESR 2), the G protein‐coupled oestrogen receptor ( GPER ) was described in the human testis but little is known about testicular GPER during development or male infertility. We performed an immunohistochemical analysis using human and rhesus monkey testicular samples. The results obtained in adult primate testes showed GPER in interstitial and vascular cells as well as in smooth muscle‐like peritubular cells, which build the wall of seminiferous tubules. Expression of GPER was also found in cultured human testicular peritubular cells ( HPTC s) by Western blotting and RT ‐ PCR /sequencing. Furthermore, as seen in time‐lapse videos of cultured cells, addition of a specific GPER agonist (G1) significantly reduced the numbers of HTPC s within 24 h. A GPER antagonist (G15) prevented this action, implying a role for GPER related to the control of cell proliferation or cell death of peritubular cells. Peritubular cell functions and their phenotype change, for example, during post‐natal development and in the cases of male infertility. The study of non‐human primate samples revealed that GPER in peritubular cells was detectable only from the time of puberty onwards, while in samples from infantile and prepubertal monkeys only interstitial cells showed immunopositive staining. In testicular biopsies of men with mixed atrophy, a reduction or loss of immunoreactive GPER was found in peritubular cells surrounding those tubules, in which spermatogenesis was impaired. In other cases of impaired spermatogenesis, namely when the tubular wall was fibrotically remodelled, a complete loss of GPER was seen. Thus, the observed inverse relation between the state of fertility and GPER expression by peritubular cells implies that the regulation of primate testicular peritubular cells by oestrogens is mediated by GPER in both, health and disease." @default.
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• W2055608506 date "2014-07-23" @default.
• W2055608506 modified "2023-10-06" @default.
• W2055608506 title "Expression of the oestrogen receptor GPER by testicular peritubular cells is linked to sexual maturation and male fertility" @default.
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• W2055608506 doi "https://doi.org/10.1111/j.2047-2927.2014.00243.x" @default.
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