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- W2055611284 abstract "A series of novel 2,4-disubstituted quinazoline derivatives were prepared and their inhibitory activities on hPin1 were evaluated. Of all the synthesized compounds, eight compounds displayed inhibitory activities with IC(50) value at the level of 10(-6)mol/L. Preliminary structure-activity relationships were analyzed in details and the binding mode of the titled compounds was predicted using FlexX algorithm. The design and optimization of novel small molecule Pin1 inhibitors will be guided by the results of this report." @default.
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- W2055611284 date "2011-05-01" @default.
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- W2055611284 title "Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors" @default.
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- W2055611284 doi "https://doi.org/10.1016/j.bmc.2011.03.058" @default.
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