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• W2055633220 endingPage "595" @default.
• W2055633220 startingPage "591" @default.
• W2055633220 abstract "N-Methyl-D-aspartate (NMDA) ([R]-2-[Methylamino]succinic acid) is a specific excitatory amino acid. Two experiments were conducted to determine the rewarding properties of this compound using the conditioned place preference paradigm. In the first experiment, 40 male Sprague-Dawley rats received place preference conditioning for a 4 day period. The conditioned place preference apparatus consisted of two chambers with distinct visual and tactile cues, separated by a removable door. On days 2 and 4, rats were systemically administered NMDA (1.0, 15.0, and 30.0 mg/kg) paired with one chamber. On days 3 and 5, rats were systemically administered saline paired with the other chamber. Day 6 was the test day, and the rat was allowed free run of the entire apparatus in a drug-free state. Time spent in each side of the apparatus was computer recorded. NMDA produced a significant increase in the amount of time spent on the side previously paired with drug for 15.0 and 30.0, but not 1.0 mg/kg NMDA. In the second experiment, systemic administration of NMDA (30.0 mg/kg) paired with the noncompetitive NMDA receptor antagonist, MK-801 (0.5 mg/kg), resulted in neither place preference nor place aversion." @default.
• W2055633220 created "2016-06-24" @default.
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• W2055633220 date "1999-11-01" @default.
• W2055633220 modified "2023-10-17" @default.
• W2055633220 title "The Rewarding Properties of NMDA and MK-801 (Dizocilpine) as Indexed by the Conditioned Place Preference Paradigm" @default.
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• W2055633220 doi "https://doi.org/10.1016/s0091-3057(99)00155-0" @default.
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