FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055645746> ?p ?o ?g. }

• W2055645746 endingPage "344" @default.
• W2055645746 startingPage "339" @default.
• W2055645746 abstract "Panax quinquefolium saponin (PQS) alleviates hypoxia-reoxygenation injury of cardiomyocytes in vitro by inhibiting excessive endoplasmic reticulum stress (ERS)–related apoptosis. We hypothesized that inhibition of excessive ERS-related apoptosis contributes to cardioprotection in ventricular remodeling after acute myocardial infarction (AMI). Sprague-Dawley rats subjected to AMI were randomly treated with water, PQS (50 mg/kg per day, 100 mg/kg per day, or 200 mg/kg per day), or taurine (300 mg/kg per day), an ERS inhibitor, for 4 weeks. Left ventricular (LV) fractional shortening, ejection fraction, and structure were then evaluated using echocardiography. Myocardial infarct size was measured by Evans blue and 2,3,5-triphenyhetrazolium chloride staining. The hydroxyproline level was assayed using the colorimetric method. Cardiomyocyte apoptosis was detected using terminal deoxynucleotidyl transferase–mediated dUTP biotin nick end labeling. In addition, expression of ERS molecules in the noninfarcted myocardium was detected using Western blotting. We found that PQS treatment significantly reduced infarct size and LV dilation and improved LV ejection fraction and fractional shortening in rat hearts. Panax quinquefolium saponin treatment also decreased hydroxyproline level in noninfarcted myocardium. Panax quinquefolium saponin treatment significantly decreased expression of glucose regulating protein 78, calreticulin, C/EBP homologous protein (CHOP), and Bax protein, as well as increased Bcl-2 protein expression in noninfarcted myocardium. Panax quinquefolium saponin treatment (200 mg/kg per day) mimicked the results achieved from the taurine-treated rats. Expression of CHOP positively correlated with the apoptosis index of cardiomyocytes in the noninfarcted myocardium (r = 0.797, P < 0.01). Taken together, PQS treatment significantly improves AMI-induced LV remodeling, and this may be attributed to inhibiting CHOP-mediated ERS-related apoptosis." @default.
• W2055645746 created "2016-06-24" @default.
• W2055645746 creator A5009408901 @default.
• W2055645746 creator A5013038112 @default.
• W2055645746 creator A5048047268 @default.
• W2055645746 creator A5059492103 @default.
• W2055645746 creator A5064505450 @default.
• W2055645746 creator A5071068810 @default.
• W2055645746 date "2013-10-01" @default.
• W2055645746 modified "2023-10-02" @default.
• W2055645746 title "Panax Quinquefolium Saponin Attenuates Ventricular Remodeling After Acute Myocardial Infarction by Inhibiting Chop-Mediated Apoptosis" @default.
• W2055645746 cites W1580272682 @default.
• W2055645746 cites W1838979040 @default.
• W2055645746 cites W1965294557 @default.
• W2055645746 cites W1982875778 @default.
• W2055645746 cites W1986189365 @default.
• W2055645746 cites W1988740497 @default.
• W2055645746 cites W1990224341 @default.
• W2055645746 cites W2000088166 @default.
• W2055645746 cites W2004232847 @default.
• W2055645746 cites W2010523651 @default.
• W2055645746 cites W2013437088 @default.
• W2055645746 cites W2021425674 @default.
• W2055645746 cites W2035545250 @default.
• W2055645746 cites W2037494323 @default.
• W2055645746 cites W2039388542 @default.
• W2055645746 cites W2043477713 @default.
• W2055645746 cites W2066062893 @default.
• W2055645746 cites W2066931754 @default.
• W2055645746 cites W2068119907 @default.
• W2055645746 cites W2069924169 @default.
• W2055645746 cites W2093918878 @default.
• W2055645746 cites W2095607155 @default.
• W2055645746 cites W2103293734 @default.
• W2055645746 cites W2115706326 @default.
• W2055645746 cites W2138302361 @default.
• W2055645746 cites W2138548325 @default.
• W2055645746 cites W2146180618 @default.
• W2055645746 cites W2159718273 @default.
• W2055645746 doi "https://doi.org/10.1097/shk.0b013e3182a3f9e5" @default.
• W2055645746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23856922" @default.
• W2055645746 hasPublicationYear "2013" @default.
• W2055645746 type Work @default.
• W2055645746 sameAs 2055645746 @default.
• W2055645746 citedByCount "36" @default.
• W2055645746 countsByYear W20556457462013 @default.
• W2055645746 countsByYear W20556457462014 @default.
• W2055645746 countsByYear W20556457462015 @default.
• W2055645746 countsByYear W20556457462016 @default.
• W2055645746 countsByYear W20556457462017 @default.
• W2055645746 countsByYear W20556457462018 @default.
• W2055645746 countsByYear W20556457462019 @default.
• W2055645746 countsByYear W20556457462020 @default.
• W2055645746 countsByYear W20556457462021 @default.
• W2055645746 countsByYear W20556457462022 @default.
• W2055645746 countsByYear W20556457462023 @default.
• W2055645746 crossrefType "journal-article" @default.
• W2055645746 hasAuthorship W2055645746A5009408901 @default.
• W2055645746 hasAuthorship W2055645746A5013038112 @default.
• W2055645746 hasAuthorship W2055645746A5048047268 @default.
• W2055645746 hasAuthorship W2055645746A5059492103 @default.
• W2055645746 hasAuthorship W2055645746A5064505450 @default.
• W2055645746 hasAuthorship W2055645746A5071068810 @default.
• W2055645746 hasConcept C126322002 @default.
• W2055645746 hasConcept C134018914 @default.
• W2055645746 hasConcept C142724271 @default.
• W2055645746 hasConcept C185592680 @default.
• W2055645746 hasConcept C190283241 @default.
• W2055645746 hasConcept C196795494 @default.
• W2055645746 hasConcept C204787440 @default.
• W2055645746 hasConcept C2778198053 @default.
• W2055645746 hasConcept C2778564307 @default.
• W2055645746 hasConcept C2779537366 @default.
• W2055645746 hasConcept C2779676291 @default.
• W2055645746 hasConcept C2779701627 @default.
• W2055645746 hasConcept C2779725641 @default.
• W2055645746 hasConcept C2779797417 @default.
• W2055645746 hasConcept C500558357 @default.
• W2055645746 hasConcept C515207424 @default.
• W2055645746 hasConcept C55493867 @default.
• W2055645746 hasConcept C71924100 @default.
• W2055645746 hasConcept C78085059 @default.
• W2055645746 hasConcept C98274493 @default.
• W2055645746 hasConceptScore W2055645746C126322002 @default.
• W2055645746 hasConceptScore W2055645746C134018914 @default.
• W2055645746 hasConceptScore W2055645746C142724271 @default.
• W2055645746 hasConceptScore W2055645746C185592680 @default.
• W2055645746 hasConceptScore W2055645746C190283241 @default.
• W2055645746 hasConceptScore W2055645746C196795494 @default.
• W2055645746 hasConceptScore W2055645746C204787440 @default.
• W2055645746 hasConceptScore W2055645746C2778198053 @default.
• W2055645746 hasConceptScore W2055645746C2778564307 @default.
• W2055645746 hasConceptScore W2055645746C2779537366 @default.
• W2055645746 hasConceptScore W2055645746C2779676291 @default.
• W2055645746 hasConceptScore W2055645746C2779701627 @default.
• W2055645746 hasConceptScore W2055645746C2779725641 @default.
• W2055645746 hasConceptScore W2055645746C2779797417 @default.
• W2055645746 hasConceptScore W2055645746C500558357 @default.

• next