Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055656278> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2055656278 endingPage "827" @default.
- W2055656278 startingPage "809" @default.
- W2055656278 abstract "This study assesses the feasibility of an intraperitoneal (IP) implantable closed-loop insulin delivery device in rats, that delivers insulin via a glucose-sensitive material such that blood glucose (BG) levels are adjusted automatically to within normal tolerances. A gateway layer of this gel governs the output of insulin from an insulin reservoir device for IP implant. The performance of the system was compared over time in diabetic rats with a control system using oral glucose challenges and daily assessments of BG and body weight. The automated response of the active system was quantified using IP multiple dose injection (MDI) results in the same rat model. Successful control was found for the device containing active gel when assessed daily and when challenged with large glucose doses. This was not found when comparing an inactive gel analog as a control. The regimen was quantified by comparison with the informative MDI study. The device was well tolerated and might operate to further advantage when vascular omentum grows into the perforated front of the device. The successful device must have been outputting approximately 0.5 U/kg/h basal with 2 U/kg boosts in order to match the demand of the challenges. However, the device eventually exhausts and a refill mechanism needs to be devised in future models." @default.
- W2055656278 created "2016-06-24" @default.
- W2055656278 creator A5011111877 @default.
- W2055656278 creator A5049262011 @default.
- W2055656278 date "1999-12-01" @default.
- W2055656278 modified "2023-09-29" @default.
- W2055656278 title "IMPLICATIONS OF THE UNITED KINGDOM PROSPECTIVE DIABETES STUDY" @default.
- W2055656278 cites W1964042918 @default.
- W2055656278 cites W1966953116 @default.
- W2055656278 cites W1975768263 @default.
- W2055656278 cites W1993448985 @default.
- W2055656278 cites W2002189587 @default.
- W2055656278 cites W2007914298 @default.
- W2055656278 cites W2014759828 @default.
- W2055656278 cites W2015899437 @default.
- W2055656278 cites W2017019560 @default.
- W2055656278 cites W2057253785 @default.
- W2055656278 cites W2069359070 @default.
- W2055656278 cites W2070945728 @default.
- W2055656278 cites W2078089300 @default.
- W2055656278 cites W2087129314 @default.
- W2055656278 cites W2090777632 @default.
- W2055656278 cites W2093977794 @default.
- W2055656278 cites W2112846582 @default.
- W2055656278 cites W2121770303 @default.
- W2055656278 cites W2128300830 @default.
- W2055656278 cites W2128864868 @default.
- W2055656278 cites W2143224383 @default.
- W2055656278 cites W2188846692 @default.
- W2055656278 cites W2324062964 @default.
- W2055656278 cites W2327295003 @default.
- W2055656278 cites W2331274940 @default.
- W2055656278 cites W2337454357 @default.
- W2055656278 cites W2769264260 @default.
- W2055656278 cites W3198570063 @default.
- W2055656278 cites W4239471829 @default.
- W2055656278 cites W4244182132 @default.
- W2055656278 cites W4245539589 @default.
- W2055656278 cites W4248956694 @default.
- W2055656278 cites W50012954 @default.
- W2055656278 doi "https://doi.org/10.1016/s0095-4543(05)70132-9" @default.
- W2055656278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10523461" @default.
- W2055656278 hasPublicationYear "1999" @default.
- W2055656278 type Work @default.
- W2055656278 sameAs 2055656278 @default.
- W2055656278 citedByCount "17" @default.
- W2055656278 countsByYear W20556562782013 @default.
- W2055656278 countsByYear W20556562782017 @default.
- W2055656278 countsByYear W20556562782023 @default.
- W2055656278 crossrefType "journal-article" @default.
- W2055656278 hasAuthorship W2055656278A5011111877 @default.
- W2055656278 hasAuthorship W2055656278A5049262011 @default.
- W2055656278 hasConcept C126322002 @default.
- W2055656278 hasConcept C134018914 @default.
- W2055656278 hasConcept C136229726 @default.
- W2055656278 hasConcept C141071460 @default.
- W2055656278 hasConcept C2778024521 @default.
- W2055656278 hasConcept C2779306644 @default.
- W2055656278 hasConcept C2781411149 @default.
- W2055656278 hasConcept C2781413609 @default.
- W2055656278 hasConcept C2983812674 @default.
- W2055656278 hasConcept C555293320 @default.
- W2055656278 hasConcept C71924100 @default.
- W2055656278 hasConceptScore W2055656278C126322002 @default.
- W2055656278 hasConceptScore W2055656278C134018914 @default.
- W2055656278 hasConceptScore W2055656278C136229726 @default.
- W2055656278 hasConceptScore W2055656278C141071460 @default.
- W2055656278 hasConceptScore W2055656278C2778024521 @default.
- W2055656278 hasConceptScore W2055656278C2779306644 @default.
- W2055656278 hasConceptScore W2055656278C2781411149 @default.
- W2055656278 hasConceptScore W2055656278C2781413609 @default.
- W2055656278 hasConceptScore W2055656278C2983812674 @default.
- W2055656278 hasConceptScore W2055656278C555293320 @default.
- W2055656278 hasConceptScore W2055656278C71924100 @default.
- W2055656278 hasIssue "4" @default.
- W2055656278 hasLocation W20556562781 @default.
- W2055656278 hasLocation W20556562782 @default.
- W2055656278 hasOpenAccess W2055656278 @default.
- W2055656278 hasPrimaryLocation W20556562781 @default.
- W2055656278 hasRelatedWork W1968873653 @default.
- W2055656278 hasRelatedWork W2004296097 @default.
- W2055656278 hasRelatedWork W2004551606 @default.
- W2055656278 hasRelatedWork W2016328345 @default.
- W2055656278 hasRelatedWork W2042819106 @default.
- W2055656278 hasRelatedWork W2048226041 @default.
- W2055656278 hasRelatedWork W2066345847 @default.
- W2055656278 hasRelatedWork W2068166803 @default.
- W2055656278 hasRelatedWork W2103498629 @default.
- W2055656278 hasRelatedWork W2430205611 @default.
- W2055656278 hasVolume "26" @default.
- W2055656278 isParatext "false" @default.
- W2055656278 isRetracted "false" @default.
- W2055656278 magId "2055656278" @default.
- W2055656278 workType "article" @default.