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• W2055667088 abstract "Abstract The effect of butylated hydroxytoluene (BHT) and diphenyl-p-phenylenediamine (DPPD) on cancer induction by N-2-fluorenylacetamide (FAA) and its N-hydroxy derivative (N-OH-FAA) has been studied in two strains of rat. Groups of Charles River rats were fed carcinogen and antioxidant in a molar ratio of 1:30 (223 ppm FAA or 239 ppm N-OH-FAA (1 mM) and 7850 ppm DPPD or 6600 ppm BHT) in Wayne Chow for 24 wk (males) or 32 wk (females). Male and female rats then continued on control diet for another 12 wk. With FAA alone 70% of male rats had hepatoma and 20% of females had mammary adenocarcinoma; with N-OH-FAA, 60% of males had hepatoma and 70% of females had mammary adenocarcinoma. The simultaneous administration of DPPD failed to alter cancer induction by these agents in male or female rats. However, BHT reduced the incidence of hepatoma in males to 20% when the carcinogen was FAA. With N-OH-FAA, BHT lowered the incidence of liver tumours to 15% and of mammary cancer in females to 35%. Similar data on inhibition by BHT were obtained using different levels of carcinogens in rats of the Fischer strain. Equimolar levels of sulphate failed to increase liver-tumour incidence in animals given N-OH-FAA and BHT. Also, BHT failed to depress the excretion of free urinary inorganic sulphate. Liver- and oesophageal-tumour induction with 51 ppm diethylnitrosamine in drinking water for 24 wk was not affected by BHT or DPPD, nor was tumour induction by propane sultone." @default.
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• W2055667088 date "1973-01-01" @default.
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• W2055667088 title "Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats" @default.
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• W2055667088 doi "https://doi.org/10.1016/s0015-6264(73)80486-9" @default.
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