FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055674384> ?p ?o ?g. }

• W2055674384 endingPage "e32807" @default.
• W2055674384 startingPage "e32807" @default.
• W2055674384 abstract "Human respiratory syncytial virus (HRSV) is the main cause of acute lower respiratory infections in children under 2 years of age and causes repeated infections throughout life. We investigated the genetic variability of RSV-A circulating in Ontario during 2010-2011 winter season by sequencing and phylogenetic analysis of the G glycoprotein gene.Among the 201 consecutive RSV isolates studied, RSV-A (55.7%) was more commonly observed than RSV-B (42.3%). 59.8% and 90.1% of RSV-A infections were among children ≤12 months and ≤5 years old, respectively. On phylogenetic analysis of the second hypervariable region of the 112 RSV-A strains, 110 (98.2%) clustered within or adjacent to the NA1 genotype; two isolates were GA5 genotype. Eleven (10%) NA1-related isolates clustered together phylogenetically as a novel RSV-A genotype, named ON1, containing a 72 nucleotide duplication in the C-terminal region of the attachment (G) glycoprotein. The predicted polypeptide is lengthened by 24 amino acids and includes a23 amino acid duplication. Using RNA secondary structural software, a possible mechanism of duplication occurrence was derived. The 23 amino acid ON1 G gene duplication results in a repeat of 7 potential O-glycosylation sites including three O-linked sugar acceptors at residues 270, 275, and 283. Using Phylogenetic Analysis by Maximum Likelihood analysis, a total of 19 positively selected sites were observed among Ontario NA1 isolates; six were found to be codons which reverted to the previous state observed in the prototype RSV-A2 strain. The tendency of codon regression in the G-ectodomain may infer a decreased avidity of antibody to the current circulating strains. Further work is needed to document and further understand the emergence, virulence, pathogenicity and transmissibility of this novel RSV-A genotype with a72 nucleotide G gene duplication." @default.
• W2055674384 created "2016-06-24" @default.
• W2055674384 creator A5003933808 @default.
• W2055674384 creator A5007833843 @default.
• W2055674384 creator A5028683444 @default.
• W2055674384 creator A5040367016 @default.
• W2055674384 creator A5053427557 @default.
• W2055674384 creator A5055080379 @default.
• W2055674384 creator A5072357134 @default.
• W2055674384 creator A5078881053 @default.
• W2055674384 date "2012-03-28" @default.
• W2055674384 modified "2023-10-03" @default.
• W2055674384 title "Genetic Variability of Human Respiratory Syncytial Virus A Strains Circulating in Ontario: A Novel Genotype with a 72 Nucleotide G Gene Duplication" @default.
• W2055674384 cites W1484385092 @default.
• W2055674384 cites W1505517791 @default.
• W2055674384 cites W1525273492 @default.
• W2055674384 cites W1589588327 @default.
• W2055674384 cites W1905840828 @default.
• W2055674384 cites W1977981962 @default.
• W2055674384 cites W1979026634 @default.
• W2055674384 cites W1979275259 @default.
• W2055674384 cites W1981046587 @default.
• W2055674384 cites W1981231649 @default.
• W2055674384 cites W1982020294 @default.
• W2055674384 cites W1987769422 @default.
• W2055674384 cites W1995372543 @default.
• W2055674384 cites W1999561390 @default.
• W2055674384 cites W2012079398 @default.
• W2055674384 cites W2016189066 @default.
• W2055674384 cites W2023346112 @default.
• W2055674384 cites W2027554854 @default.
• W2055674384 cites W2034319418 @default.
• W2055674384 cites W2043162873 @default.
• W2055674384 cites W2048205813 @default.
• W2055674384 cites W2049373555 @default.
• W2055674384 cites W2049970850 @default.
• W2055674384 cites W2050045787 @default.
• W2055674384 cites W2052402839 @default.
• W2055674384 cites W2055450907 @default.
• W2055674384 cites W2060190614 @default.
• W2055674384 cites W2065461553 @default.
• W2055674384 cites W2074512725 @default.
• W2055674384 cites W2081114699 @default.
• W2055674384 cites W2082633121 @default.
• W2055674384 cites W2088644418 @default.
• W2055674384 cites W2094147095 @default.
• W2055674384 cites W2099308320 @default.
• W2055674384 cites W2100360941 @default.
• W2055674384 cites W2103103974 @default.
• W2055674384 cites W2110335151 @default.
• W2055674384 cites W2115035645 @default.
• W2055674384 cites W2115517252 @default.
• W2055674384 cites W2119627949 @default.
• W2055674384 cites W2121831414 @default.
• W2055674384 cites W2122182826 @default.
• W2055674384 cites W2124932154 @default.
• W2055674384 cites W2131354424 @default.
• W2055674384 cites W2132319121 @default.
• W2055674384 cites W2132632499 @default.
• W2055674384 cites W2133519886 @default.
• W2055674384 cites W2150396170 @default.
• W2055674384 cites W2159404943 @default.
• W2055674384 cites W2161433430 @default.
• W2055674384 cites W2163986700 @default.
• W2055674384 cites W2164593458 @default.
• W2055674384 cites W2166096923 @default.
• W2055674384 cites W2166720212 @default.
• W2055674384 cites W2170565120 @default.
• W2055674384 cites W2202851436 @default.
• W2055674384 doi "https://doi.org/10.1371/journal.pone.0032807" @default.
• W2055674384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3314658" @default.
• W2055674384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22470426" @default.
• W2055674384 hasPublicationYear "2012" @default.
• W2055674384 type Work @default.
• W2055674384 sameAs 2055674384 @default.
• W2055674384 citedByCount "258" @default.
• W2055674384 countsByYear W20556743842012 @default.
• W2055674384 countsByYear W20556743842013 @default.
• W2055674384 countsByYear W20556743842014 @default.
• W2055674384 countsByYear W20556743842015 @default.
• W2055674384 countsByYear W20556743842016 @default.
• W2055674384 countsByYear W20556743842017 @default.
• W2055674384 countsByYear W20556743842018 @default.
• W2055674384 countsByYear W20556743842019 @default.
• W2055674384 countsByYear W20556743842020 @default.
• W2055674384 countsByYear W20556743842021 @default.
• W2055674384 countsByYear W20556743842022 @default.
• W2055674384 countsByYear W20556743842023 @default.
• W2055674384 crossrefType "journal-article" @default.
• W2055674384 hasAuthorship W2055674384A5003933808 @default.
• W2055674384 hasAuthorship W2055674384A5007833843 @default.
• W2055674384 hasAuthorship W2055674384A5028683444 @default.
• W2055674384 hasAuthorship W2055674384A5040367016 @default.
• W2055674384 hasAuthorship W2055674384A5053427557 @default.
• W2055674384 hasAuthorship W2055674384A5055080379 @default.
• W2055674384 hasAuthorship W2055674384A5072357134 @default.
• W2055674384 hasAuthorship W2055674384A5078881053 @default.
• W2055674384 hasBestOaLocation W20556743841 @default.

• next