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- W2055682080 abstract "The modulating effect of interferon-gamma (IFN-gamma) and polyclonal immunoglobulin (poly-Ig) on mineral dust-induced production of reactive oxygen metabolites (ROM) by human monocyte-derived macrophages was investigated using lucigenin-dependent chemiluminescence. Activation of the cell cultures with IFN-gamma enhanced the subsequent quartz- and asbestos-induced production of ROM, while the addition of poly-Ig only stimulated chrysotile asbestos-induced ROM production. The combination of IFN activation and the addition of poly-Ig to the reactions caused a 20-fold enhancement of the responses to chrysotile. As increased levels of IFN-gamma and immunoglobulins have been observed in patients with mineral dust-induced diseases, we suggest that immunological activation caused by, for example, autoimmune diseases or recurrent pulmonary infections might amplify the production of potentially tissue-injuring ROM by mononuclear phagocytes and may possibly determine the individual susceptibility to mineral dust-related disorders." @default.
- W2055682080 created "2016-06-24" @default.
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- W2055682080 date "1991-07-01" @default.
- W2055682080 modified "2023-10-16" @default.
- W2055682080 title "Interferon-γ and immunoglobulin enhance mineral dust-induced production of reactive oxygen metabolites by human macrophages" @default.
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- W2055682080 doi "https://doi.org/10.1016/0090-1229(91)90118-t" @default.
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