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- W2055692021 abstract "Mouse brain γ-aminobutyrate aminotransferase was inactivated by phenylglyoxal in a time and concentration dependent manner. Pyridoxal phosphate but not γ-aminobutyric acid or α-ketoglutarate afforded some protection against the drug-induced inactivation. [14C]Phenylglyoxal was incorporated into the enzyme at a similar rate to that of the inactivation. Subsequent hydrolysis of the enzyme demonstrated the presence of a [14] phenylglyoxal-arginine complex. The phenylglyoxal is probably modifying an arginine residue at or near the pyridoxal phosphate binding site of γ-aminobutyrate aminotransferase." @default.
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- W2055692021 title "Essential arginine residues at the pyridoxal phosphate binding site of brain γ-aminobutyrate aminotransferase" @default.
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- W2055692021 doi "https://doi.org/10.1016/s0006-291x(80)80149-5" @default.
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