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• W2055697777 abstract "The inherent or acquired resistance of certain tumors to cytotoxic drug therapy is a major clinical problem. Resistance to the chemotherapeutic antimetabolites (e.g., methotrexate, 5-fluorouracil, tomudex and gemcitabine) is no exception. Mechanisms of resistance include mutations, amplification of target genes, altered drug transport, differences in nucleoside and nucleobase salvage pathways, DNA damage-response pathways and cell cycle control pathways." @default.
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• W2055697777 date "1998-05-01" @default.
• W2055697777 modified "2023-09-27" @default.
• W2055697777 title "Tumor Resistance To Antimetabolites" @default.
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• W2055697777 doi "https://doi.org/10.1016/s0306-3623(97)00383-2" @default.
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