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- W2055698723 abstract "Nucleosomes are the ubiquitous and fundamental packaging for eukaryotic genomes, and are the substrate for many processes in the nucleus. Nucleosomes are not static entities but can readily be moved by thermal energy and ATP-dependent chromatin remodeling complexes in a process known as sliding or shifting. We summarize from a mechanical perspective the twist defect and bulge diffusion mechanisms proposed as the most likely pathway for nucleosome mobilization. We then consider the elastic properties of DNA and how this affects the potential for each mechanism, concentrating on kinetic aspects of twist diffusion and possible planar bulge sizes and summarize the experimental evidence reflecting on each. Either, or both, mechanisms could occur, and careful experimentation focusing on their uniquely distinguishing features will be required to determine their relative contributions to chromatin dynamics." @default.
- W2055698723 created "2016-06-24" @default.
- W2055698723 creator A5007965740 @default.
- W2055698723 creator A5054115157 @default.
- W2055698723 date "2003-02-26" @default.
- W2055698723 modified "2023-10-15" @default.
- W2055698723 title "Mechanisms for nucleosome mobilization" @default.
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- W2055698723 doi "https://doi.org/10.1002/bip.10323" @default.
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