FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055698835> ?p ?o ?g. }

• W2055698835 endingPage "1529" @default.
• W2055698835 startingPage "1523" @default.
• W2055698835 abstract "Summary. Background: Cardiopulmonary bypass and coronary artery bypass grafting (CABG) result in significant thrombin generation and activation of fibrinolysis. Thrombin contributes to myocardial ischemia–reperfusion injury in animal studies, but the role of thrombin in myocardial damage after CABG is unknown. Objectives: We measured thrombin generation and fibrin turnover during reperfusion after CABG to evaluate their associations with postoperative hemodynamic changes and myocardial damage. Methods: One hundred patients undergoing primary, elective, on-pump CABG were prospectively enrolled. Plasma prothrombin fragment F1+2 and D-dimer were measured preoperatively and at seven time points thereafter. Mass of the Mb fraction of creatine kinase (Ck-Mbm) and troponin T (TnT) were measured on the first postoperative day. Results: Reperfusion induced an escalation of thrombin generation and fibrin turnover despite full heparinization. F1+2 during early reperfusion associated with postoperative pulmonary vascular resistance index. F1+2 at 6 h after protamine administration correlated with Ck-Mbm (r = 0.40, P < 0.001) and TnT (r = 0.44, P < 0.001) at 18 h postoperatively. Patients with evidence of myocardial damage (highest quintiles of plasma Ck-Mbm and TnT) had significantly higher F1+2 during reperfusion than others (P < 0.002). Logistic regression models identified F1+2 during reperfusion to independently associate with postoperative myocardial damage (odds ratios 2.5–4.4, 95% confidence intervals 1.04–15.7). Conclusions: Reperfusion caused a burst in thrombin generation and fibrin turnover despite generous heparinization. Thrombin generation during reperfusion after CABG associated with pulmonary vascular resistance and postoperative myocardial damage." @default.
• W2055698835 created "2016-06-24" @default.
• W2055698835 creator A5021578807 @default.
• W2055698835 creator A5026351609 @default.
• W2055698835 creator A5051498958 @default.
• W2055698835 creator A5052605844 @default.
• W2055698835 creator A5055770780 @default.
• W2055698835 date "2006-07-01" @default.
• W2055698835 modified "2023-09-30" @default.
• W2055698835 title "Thrombin generation during reperfusion after coronary artery bypass surgery associates with postoperative myocardial damage" @default.
• W2055698835 cites W1739627328 @default.
• W2055698835 cites W177712551 @default.
• W2055698835 cites W1966238845 @default.
• W2055698835 cites W1966951186 @default.
• W2055698835 cites W2002013932 @default.
• W2055698835 cites W2004402776 @default.
• W2055698835 cites W2006921796 @default.
• W2055698835 cites W2011101439 @default.
• W2055698835 cites W2024773717 @default.
• W2055698835 cites W2026829115 @default.
• W2055698835 cites W2029970434 @default.
• W2055698835 cites W2036156739 @default.
• W2055698835 cites W2043011155 @default.
• W2055698835 cites W2044192771 @default.
• W2055698835 cites W2045691857 @default.
• W2055698835 cites W2078457377 @default.
• W2055698835 cites W2081356898 @default.
• W2055698835 cites W2104810826 @default.
• W2055698835 cites W2107124264 @default.
• W2055698835 cites W2121779915 @default.
• W2055698835 cites W2144817855 @default.
• W2055698835 cites W2160422611 @default.
• W2055698835 cites W30189465 @default.
• W2055698835 doi "https://doi.org/10.1111/j.1538-7836.2006.02028.x" @default.
• W2055698835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16839349" @default.
• W2055698835 hasPublicationYear "2006" @default.
• W2055698835 type Work @default.
• W2055698835 sameAs 2055698835 @default.
• W2055698835 citedByCount "32" @default.
• W2055698835 countsByYear W20556988352012 @default.
• W2055698835 countsByYear W20556988352013 @default.
• W2055698835 countsByYear W20556988352014 @default.
• W2055698835 countsByYear W20556988352016 @default.
• W2055698835 countsByYear W20556988352018 @default.
• W2055698835 countsByYear W20556988352020 @default.
• W2055698835 countsByYear W20556988352022 @default.
• W2055698835 crossrefType "journal-article" @default.
• W2055698835 hasAuthorship W2055698835A5021578807 @default.
• W2055698835 hasAuthorship W2055698835A5026351609 @default.
• W2055698835 hasAuthorship W2055698835A5051498958 @default.
• W2055698835 hasAuthorship W2055698835A5052605844 @default.
• W2055698835 hasAuthorship W2055698835A5055770780 @default.
• W2055698835 hasConcept C126322002 @default.
• W2055698835 hasConcept C144469398 @default.
• W2055698835 hasConcept C164705383 @default.
• W2055698835 hasConcept C178853913 @default.
• W2055698835 hasConcept C203014093 @default.
• W2055698835 hasConcept C2775901492 @default.
• W2055698835 hasConcept C2776820930 @default.
• W2055698835 hasConcept C2777292125 @default.
• W2055698835 hasConcept C2778881276 @default.
• W2055698835 hasConcept C2780114680 @default.
• W2055698835 hasConcept C2780387585 @default.
• W2055698835 hasConcept C36880943 @default.
• W2055698835 hasConcept C42219234 @default.
• W2055698835 hasConcept C500558357 @default.
• W2055698835 hasConcept C54173615 @default.
• W2055698835 hasConcept C541997718 @default.
• W2055698835 hasConcept C58245268 @default.
• W2055698835 hasConcept C71924100 @default.
• W2055698835 hasConcept C89560881 @default.
• W2055698835 hasConceptScore W2055698835C126322002 @default.
• W2055698835 hasConceptScore W2055698835C144469398 @default.
• W2055698835 hasConceptScore W2055698835C164705383 @default.
• W2055698835 hasConceptScore W2055698835C178853913 @default.
• W2055698835 hasConceptScore W2055698835C203014093 @default.
• W2055698835 hasConceptScore W2055698835C2775901492 @default.
• W2055698835 hasConceptScore W2055698835C2776820930 @default.
• W2055698835 hasConceptScore W2055698835C2777292125 @default.
• W2055698835 hasConceptScore W2055698835C2778881276 @default.
• W2055698835 hasConceptScore W2055698835C2780114680 @default.
• W2055698835 hasConceptScore W2055698835C2780387585 @default.
• W2055698835 hasConceptScore W2055698835C36880943 @default.
• W2055698835 hasConceptScore W2055698835C42219234 @default.
• W2055698835 hasConceptScore W2055698835C500558357 @default.
• W2055698835 hasConceptScore W2055698835C54173615 @default.
• W2055698835 hasConceptScore W2055698835C541997718 @default.
• W2055698835 hasConceptScore W2055698835C58245268 @default.
• W2055698835 hasConceptScore W2055698835C71924100 @default.
• W2055698835 hasConceptScore W2055698835C89560881 @default.
• W2055698835 hasIssue "7" @default.
• W2055698835 hasLocation W20556988351 @default.
• W2055698835 hasLocation W20556988352 @default.
• W2055698835 hasOpenAccess W2055698835 @default.
• W2055698835 hasPrimaryLocation W20556988351 @default.
• W2055698835 hasRelatedWork W2013387716 @default.
• W2055698835 hasRelatedWork W2034330530 @default.
• W2055698835 hasRelatedWork W2045691857 @default.

• next