Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055699118> ?p ?o ?g. }
- W2055699118 abstract "We investigated the relaxant effect of vasoactive intestinal polypeptide (VIP) in trachea and lung parenchyma from normal and sensitized guinea-pigs. A technique by which drug access was restricted to either the mucosal or the adventitial surface of tracheal rings was used. In intact trachea, concentration-response curves for VIP entering from the mucosal surface (pD2 = 6.61 +/- 0.06) were displaced to the right compared with those for adventitial entry (pD2 = 6.78 +/- 0.04). Epithelium removal produced a leftward shift (approximately 2.8-fold) in the mucosal VIP concentration-response curve. Sensitization did not alter the responsiveness (maximal effect) or sensitivity (pD2 values) of tracheal rings to VIP irrespective of the surface of drug entry and of the absence or presence of epithelium. VIP-induced relaxation of normal and sensitized lung strips was also similar. Sensitization resulted in a significant decrease in tracheal VIP content (from 2.16 +/- 0.07 in normal to 0.60 +/- 0.08 nmol/mg protein in sensitized trachea; P < 0.05; n = 7) whereas the affinity of both high- and low-affinity binding sites for VIP increased as compared to that of normal trachea. Differences were not found in the binding capacities of normal and sensitized trachea. VIP content and binding did not differ in normal and sensitized lung. In conclusion, immunological sensitization produced changes in VIP tracheal content and binding but neither VIP-induced relaxation of isolated airways nor the influence of epithelium in this response was altered." @default.
- W2055699118 created "2016-06-24" @default.
- W2055699118 creator A5003086206 @default.
- W2055699118 creator A5007459072 @default.
- W2055699118 creator A5017323707 @default.
- W2055699118 creator A5024080563 @default.
- W2055699118 creator A5036770039 @default.
- W2055699118 creator A5064738887 @default.
- W2055699118 creator A5069946536 @default.
- W2055699118 creator A5075205805 @default.
- W2055699118 date "1993-12-01" @default.
- W2055699118 modified "2023-09-27" @default.
- W2055699118 title "Effects of sensitization on vasoactive intestinal polypeptide-induced relaxation and its concentration and binding in guinea-pig airways" @default.
- W2055699118 cites W154829778 @default.
- W2055699118 cites W1964014423 @default.
- W2055699118 cites W1965016397 @default.
- W2055699118 cites W1983649348 @default.
- W2055699118 cites W1986127219 @default.
- W2055699118 cites W1986666795 @default.
- W2055699118 cites W1989584865 @default.
- W2055699118 cites W1990760230 @default.
- W2055699118 cites W1990879885 @default.
- W2055699118 cites W1999917364 @default.
- W2055699118 cites W2003763178 @default.
- W2055699118 cites W2005595324 @default.
- W2055699118 cites W2009067219 @default.
- W2055699118 cites W2010858756 @default.
- W2055699118 cites W2011521821 @default.
- W2055699118 cites W2013533988 @default.
- W2055699118 cites W2015096089 @default.
- W2055699118 cites W2017040378 @default.
- W2055699118 cites W2025372434 @default.
- W2055699118 cites W2038653961 @default.
- W2055699118 cites W2043813981 @default.
- W2055699118 cites W2044204746 @default.
- W2055699118 cites W2044435391 @default.
- W2055699118 cites W2045166690 @default.
- W2055699118 cites W2048450126 @default.
- W2055699118 cites W2048556307 @default.
- W2055699118 cites W2057734996 @default.
- W2055699118 cites W2058285287 @default.
- W2055699118 cites W2060067571 @default.
- W2055699118 cites W2061432016 @default.
- W2055699118 cites W2063746758 @default.
- W2055699118 cites W2063762500 @default.
- W2055699118 cites W2069168371 @default.
- W2055699118 cites W2074201506 @default.
- W2055699118 cites W2082897359 @default.
- W2055699118 cites W2121192663 @default.
- W2055699118 cites W2158551444 @default.
- W2055699118 cites W2257252244 @default.
- W2055699118 cites W2402975138 @default.
- W2055699118 cites W2415669820 @default.
- W2055699118 cites W2475014436 @default.
- W2055699118 doi "https://doi.org/10.1016/0014-2999(93)90394-w" @default.
- W2055699118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8112387" @default.
- W2055699118 hasPublicationYear "1993" @default.
- W2055699118 type Work @default.
- W2055699118 sameAs 2055699118 @default.
- W2055699118 citedByCount "2" @default.
- W2055699118 crossrefType "journal-article" @default.
- W2055699118 hasAuthorship W2055699118A5003086206 @default.
- W2055699118 hasAuthorship W2055699118A5007459072 @default.
- W2055699118 hasAuthorship W2055699118A5017323707 @default.
- W2055699118 hasAuthorship W2055699118A5024080563 @default.
- W2055699118 hasAuthorship W2055699118A5036770039 @default.
- W2055699118 hasAuthorship W2055699118A5064738887 @default.
- W2055699118 hasAuthorship W2055699118A5069946536 @default.
- W2055699118 hasAuthorship W2055699118A5075205805 @default.
- W2055699118 hasConcept C118303440 @default.
- W2055699118 hasConcept C126322002 @default.
- W2055699118 hasConcept C134018914 @default.
- W2055699118 hasConcept C170493617 @default.
- W2055699118 hasConcept C185592680 @default.
- W2055699118 hasConcept C203014093 @default.
- W2055699118 hasConcept C2776217527 @default.
- W2055699118 hasConcept C2777714996 @default.
- W2055699118 hasConcept C2778815084 @default.
- W2055699118 hasConcept C2779644171 @default.
- W2055699118 hasConcept C534529494 @default.
- W2055699118 hasConcept C71924100 @default.
- W2055699118 hasConcept C8330315 @default.
- W2055699118 hasConceptScore W2055699118C118303440 @default.
- W2055699118 hasConceptScore W2055699118C126322002 @default.
- W2055699118 hasConceptScore W2055699118C134018914 @default.
- W2055699118 hasConceptScore W2055699118C170493617 @default.
- W2055699118 hasConceptScore W2055699118C185592680 @default.
- W2055699118 hasConceptScore W2055699118C203014093 @default.
- W2055699118 hasConceptScore W2055699118C2776217527 @default.
- W2055699118 hasConceptScore W2055699118C2777714996 @default.
- W2055699118 hasConceptScore W2055699118C2778815084 @default.
- W2055699118 hasConceptScore W2055699118C2779644171 @default.
- W2055699118 hasConceptScore W2055699118C534529494 @default.
- W2055699118 hasConceptScore W2055699118C71924100 @default.
- W2055699118 hasConceptScore W2055699118C8330315 @default.
- W2055699118 hasLocation W20556991181 @default.
- W2055699118 hasLocation W20556991182 @default.
- W2055699118 hasOpenAccess W2055699118 @default.
- W2055699118 hasPrimaryLocation W20556991181 @default.
- W2055699118 hasRelatedWork W1995406054 @default.