Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055702014> ?p ?o ?g. }
- W2055702014 endingPage "607" @default.
- W2055702014 startingPage "593" @default.
- W2055702014 abstract "Alzheimer’s disease (AD) is characterized by three major histopathological hallmarks: β-amyloid deposits, neurofibrillary tangles and gliosis. While neglected for decades, the neuroinflammatory processes coordinated by microglia are now accepted as etiologic events in AD evolution. Microglial cells are found in close vicinity to amyloid plaques and display various activation phenotypes determined by the expression of a wide range of cytokines, chemokines, and innate immune surface receptors. During the development of AD pathology, microglia fail to restrict amyloid plaques and may contribute to neurotoxicity and cognitive deficit. Nevertheless, under specific activation states, microglia can participate in cerebral amyloid clearance. This review focuses on the complex relationship between microglia and Aβ pathology, and highlights both deleterious and beneficial roles of microglial activation states in the context of AD. A deeper understanding of microglial biology will hopefully pave the way for next-generation AD therapeutic approaches aimed at harnessing these enigmatic innate immune cells of the central nervous system. Keywords: Alzheimer disease, amyloid-β peptide, chemokine, cytokine, gliosis, inflammation, innate immunity, microglia, neuroinflammation, phagocytosis." @default.
- W2055702014 created "2016-06-24" @default.
- W2055702014 creator A5016366290 @default.
- W2055702014 creator A5080669205 @default.
- W2055702014 date "2013-07-01" @default.
- W2055702014 modified "2023-10-02" @default.
- W2055702014 title "Innate Immunity in Alzheimer’s Disease: A Complex Affair" @default.
- W2055702014 cites W109402025 @default.
- W2055702014 cites W1250647964 @default.
- W2055702014 cites W147870220 @default.
- W2055702014 cites W1481263059 @default.
- W2055702014 cites W1503511302 @default.
- W2055702014 cites W1536467313 @default.
- W2055702014 cites W1567490604 @default.
- W2055702014 cites W1575263086 @default.
- W2055702014 cites W1586876258 @default.
- W2055702014 cites W1595078459 @default.
- W2055702014 cites W1613451007 @default.
- W2055702014 cites W1616122655 @default.
- W2055702014 cites W1617304195 @default.
- W2055702014 cites W1621971853 @default.
- W2055702014 cites W1893620705 @default.
- W2055702014 cites W1916393557 @default.
- W2055702014 cites W1937826833 @default.
- W2055702014 cites W1965275873 @default.
- W2055702014 cites W1966081154 @default.
- W2055702014 cites W1966510897 @default.
- W2055702014 cites W1967464880 @default.
- W2055702014 cites W1967570428 @default.
- W2055702014 cites W1968615956 @default.
- W2055702014 cites W1968794453 @default.
- W2055702014 cites W1970347605 @default.
- W2055702014 cites W1971003242 @default.
- W2055702014 cites W1971805587 @default.
- W2055702014 cites W1971963029 @default.
- W2055702014 cites W1972637602 @default.
- W2055702014 cites W1972644884 @default.
- W2055702014 cites W1972784541 @default.
- W2055702014 cites W1973238388 @default.
- W2055702014 cites W1974966491 @default.
- W2055702014 cites W1975919336 @default.
- W2055702014 cites W1977775233 @default.
- W2055702014 cites W1977896329 @default.
- W2055702014 cites W1979343445 @default.
- W2055702014 cites W1979507013 @default.
- W2055702014 cites W1981614925 @default.
- W2055702014 cites W1982815317 @default.
- W2055702014 cites W1984285433 @default.
- W2055702014 cites W1984673216 @default.
- W2055702014 cites W1984889847 @default.
- W2055702014 cites W1984958202 @default.
- W2055702014 cites W1985157285 @default.
- W2055702014 cites W1985577963 @default.
- W2055702014 cites W1989300299 @default.
- W2055702014 cites W1989634440 @default.
- W2055702014 cites W1990636293 @default.
- W2055702014 cites W1991763618 @default.
- W2055702014 cites W1993909442 @default.
- W2055702014 cites W1995365045 @default.
- W2055702014 cites W1998079087 @default.
- W2055702014 cites W1998282006 @default.
- W2055702014 cites W2000665176 @default.
- W2055702014 cites W2001210466 @default.
- W2055702014 cites W2001334299 @default.
- W2055702014 cites W2001717792 @default.
- W2055702014 cites W2002774469 @default.
- W2055702014 cites W2003186557 @default.
- W2055702014 cites W2005076304 @default.
- W2055702014 cites W2006505402 @default.
- W2055702014 cites W2009639401 @default.
- W2055702014 cites W2010464023 @default.
- W2055702014 cites W2016628359 @default.
- W2055702014 cites W2017608412 @default.
- W2055702014 cites W2018563185 @default.
- W2055702014 cites W2018708829 @default.
- W2055702014 cites W2021260035 @default.
- W2055702014 cites W2024627685 @default.
- W2055702014 cites W2028771127 @default.
- W2055702014 cites W2031743210 @default.
- W2055702014 cites W2032935702 @default.
- W2055702014 cites W2033224335 @default.
- W2055702014 cites W2033966441 @default.
- W2055702014 cites W2036094153 @default.
- W2055702014 cites W2038031810 @default.
- W2055702014 cites W2038182267 @default.
- W2055702014 cites W2038833833 @default.
- W2055702014 cites W2038943581 @default.
- W2055702014 cites W2038967600 @default.
- W2055702014 cites W2040746032 @default.
- W2055702014 cites W2042754407 @default.
- W2055702014 cites W2044488773 @default.
- W2055702014 cites W2045560271 @default.
- W2055702014 cites W2045720033 @default.
- W2055702014 cites W2046673854 @default.
- W2055702014 cites W2047658053 @default.
- W2055702014 cites W2047964142 @default.
- W2055702014 cites W2049167261 @default.
- W2055702014 cites W2049733399 @default.