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- W2055705934 abstract "We report a combined dynamic light scattering (DLS) and neutron spin-echo (NSE) study on the local bilayer undulation dynamics of phospholipid vesicles composed of 1,2-dimyristoyl-glycero-3-phosphatidylcholine (DMPC) under the influence of temperature and the additives cholesterol and trehalose. The additives affect vesicle size and self-diffusion. Mechanical properties of the membrane and corresponding bilayer undulations are tuned by changing lipid headgroup or acyl chain properties through temperature or composition. On the local length scale, changes at the lipid headgroup influence the bilayer bending rigidity κ less than changes at the lipid acyl chain: We observe a bilayer softening around the main phase transition temperature Tm of the single lipid system, and stiffening when more cholesterol is added, in concordance with literature. Surprisingly, no effect on the mechanical properties of the vesicles is observed upon the addition of trehalose." @default.
- W2055705934 created "2016-06-24" @default.
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- W2055705934 date "2014-10-01" @default.
- W2055705934 modified "2023-09-27" @default.
- W2055705934 title "Bilayer undulation dynamics in unilamellar phospholipid vesicles: Effect of temperature, cholesterol and trehalose" @default.
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- W2055705934 doi "https://doi.org/10.1016/j.bbamem.2014.06.006" @default.
- W2055705934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24950248" @default.
- W2055705934 hasPublicationYear "2014" @default.
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