Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055728118> ?p ?o ?g. }
- W2055728118 endingPage "2058" @default.
- W2055728118 startingPage "2048" @default.
- W2055728118 abstract "Many DNA lesions cause pausing of replication forks at lesion sites; thus, generating gaps in the daughter strands that are filled-in by post-replication repair (PRR) pathways. In Saccharomyces cerevisiae, PRR involves translesion synthesis (TLS) mediated by Poleta or Polzeta, or Rad5-dependent gap filling through a poorly characterized error-free mechanism. We have developed an assay to monitor error-free and mutagenic TLS across single DNA lesions in Schizosaccharomyces pombe. For both main UV photolesions, we have delineated a major error-free pathway mediated by a distinct combination of TLS polymerases. Surprisingly, these TLS pathways require enzymes needed for poly-ubiquitination of proliferating cell nuclear antigen (PCNA) as well as those required for mono-ubiquitination. For pathways that require several TLS polymerases the poly-ubiquitin chains of PCNA may facilitate their recruitment through specific interactions with their multiple ubiquitin-binding motifs. These error-free TLS pathways may at least partially account for the previously described poly-ubiquitination-dependent error-free branch of PRR. This work highlights major differences in the control of lesion tolerance pathways between S. pombe and S. cerevisiae despite the homologous sets of PRR genes these organisms share." @default.
- W2055728118 created "2016-06-24" @default.
- W2055728118 creator A5023407735 @default.
- W2055728118 creator A5035334632 @default.
- W2055728118 creator A5048471316 @default.
- W2055728118 creator A5073569847 @default.
- W2055728118 creator A5076917810 @default.
- W2055728118 creator A5083864892 @default.
- W2055728118 date "2010-05-07" @default.
- W2055728118 modified "2023-09-24" @default.
- W2055728118 title "Rad8Rad5/Mms2–Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast" @default.
- W2055728118 cites W1531823089 @default.
- W2055728118 cites W1840855988 @default.
- W2055728118 cites W1964529737 @default.
- W2055728118 cites W1968437581 @default.
- W2055728118 cites W1968679294 @default.
- W2055728118 cites W1973443491 @default.
- W2055728118 cites W1974875206 @default.
- W2055728118 cites W1980578402 @default.
- W2055728118 cites W1984036570 @default.
- W2055728118 cites W1985245436 @default.
- W2055728118 cites W1985746590 @default.
- W2055728118 cites W1989434869 @default.
- W2055728118 cites W1990265320 @default.
- W2055728118 cites W1994502400 @default.
- W2055728118 cites W2002635441 @default.
- W2055728118 cites W2003928652 @default.
- W2055728118 cites W2009214067 @default.
- W2055728118 cites W2010228033 @default.
- W2055728118 cites W2016511045 @default.
- W2055728118 cites W2020136215 @default.
- W2055728118 cites W2028157992 @default.
- W2055728118 cites W2032004743 @default.
- W2055728118 cites W2037751651 @default.
- W2055728118 cites W2047452116 @default.
- W2055728118 cites W2051435128 @default.
- W2055728118 cites W2056139483 @default.
- W2055728118 cites W2056595058 @default.
- W2055728118 cites W2062487397 @default.
- W2055728118 cites W2065286203 @default.
- W2055728118 cites W2070184285 @default.
- W2055728118 cites W2070910548 @default.
- W2055728118 cites W2072747624 @default.
- W2055728118 cites W2083123225 @default.
- W2055728118 cites W2085866527 @default.
- W2055728118 cites W2099350256 @default.
- W2055728118 cites W2119301405 @default.
- W2055728118 cites W2127144937 @default.
- W2055728118 cites W2134678790 @default.
- W2055728118 cites W2135713533 @default.
- W2055728118 cites W2135858046 @default.
- W2055728118 cites W2143064529 @default.
- W2055728118 cites W2145269684 @default.
- W2055728118 cites W2149736406 @default.
- W2055728118 cites W2163790016 @default.
- W2055728118 cites W2169950973 @default.
- W2055728118 cites W2170604785 @default.
- W2055728118 cites W2194986544 @default.
- W2055728118 doi "https://doi.org/10.1038/emboj.2010.87" @default.
- W2055728118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2892369" @default.
- W2055728118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20453833" @default.
- W2055728118 hasPublicationYear "2010" @default.
- W2055728118 type Work @default.
- W2055728118 sameAs 2055728118 @default.
- W2055728118 citedByCount "37" @default.
- W2055728118 countsByYear W20557281182012 @default.
- W2055728118 countsByYear W20557281182013 @default.
- W2055728118 countsByYear W20557281182014 @default.
- W2055728118 countsByYear W20557281182015 @default.
- W2055728118 countsByYear W20557281182016 @default.
- W2055728118 countsByYear W20557281182017 @default.
- W2055728118 countsByYear W20557281182018 @default.
- W2055728118 countsByYear W20557281182019 @default.
- W2055728118 countsByYear W20557281182020 @default.
- W2055728118 countsByYear W20557281182021 @default.
- W2055728118 countsByYear W20557281182022 @default.
- W2055728118 crossrefType "journal-article" @default.
- W2055728118 hasAuthorship W2055728118A5023407735 @default.
- W2055728118 hasAuthorship W2055728118A5035334632 @default.
- W2055728118 hasAuthorship W2055728118A5048471316 @default.
- W2055728118 hasAuthorship W2055728118A5073569847 @default.
- W2055728118 hasAuthorship W2055728118A5076917810 @default.
- W2055728118 hasAuthorship W2055728118A5083864892 @default.
- W2055728118 hasBestOaLocation W20557281182 @default.
- W2055728118 hasConcept C104317684 @default.
- W2055728118 hasConcept C104451858 @default.
- W2055728118 hasConcept C134459356 @default.
- W2055728118 hasConcept C134935766 @default.
- W2055728118 hasConcept C143425029 @default.
- W2055728118 hasConcept C175114707 @default.
- W2055728118 hasConcept C182561583 @default.
- W2055728118 hasConcept C23458808 @default.
- W2055728118 hasConcept C25602115 @default.
- W2055728118 hasConcept C2776519988 @default.
- W2055728118 hasConcept C2777576037 @default.
- W2055728118 hasConcept C2779222958 @default.
- W2055728118 hasConcept C2779429346 @default.
- W2055728118 hasConcept C34688535 @default.