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- W2055731724 abstract "In this work, we derive a simple mathematical model from mass-action equations for amyloid fiber formation that takes into account the primary nucleation, elongation, and length-dependent fragmentation. The derivation is based on the principle of minimum free energy under certain constraints and is mathematically related to the partial equilibrium approximation. Direct numerical comparisons confirm the usefulness of our simple model. We further explore its basic kinetic and equilibrium properties, and show that the current model is a straightforward generalization of that with constant fragmentation rates." @default.
- W2055731724 created "2016-06-24" @default.
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- W2055731724 date "2013-02-01" @default.
- W2055731724 modified "2023-10-17" @default.
- W2055731724 title "Simple Moment-Closure Model for the Self-Assembly of Breakable Amyloid Filaments" @default.
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- W2055731724 doi "https://doi.org/10.1016/j.bpj.2012.12.039" @default.
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