FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055742349> ?p ?o ?g. }

• W2055742349 endingPage "11211" @default.
• W2055742349 startingPage "11206" @default.
• W2055742349 abstract "The recent, unexpected discovery of a functional DNA methylation system in the genome of the social bee Apis mellifera underscores the potential importance of DNA methylation in invertebrates. The extent of genomic DNA methylation and its role in A. mellifera remain unknown, however. Here we show that genes in A. mellifera can be divided into 2 distinct classes, one with low-CpG dinucleotide content and the other with high-CpG dinucleotide content. This dichotomy is explained by the gradual depletion of CpG dinucleotides, a well-known consequence of DNA methylation. The loss of CpG dinucleotides associated with DNA methylation also may explain the unusual mutational patterns seen in A. mellifera that lead to AT-rich regions of the genome. A detailed investigation of this dichotomy implicates DNA methylation in A. mellifera development. High-CpG genes, which are predicted to be hypomethylated in germlines, are enriched with functions associated with developmental processes, whereas low-CpG genes, predicted to be hypermethylated in germlines, are enriched with functions associated with basic biological processes. Furthermore, genes more highly expressed in one caste than another are overrepresented among high-CpG genes. Our results highlight the potential significance of epigenetic modifications, such as DNA methylation, in developmental processes in social insects. In particular, the pervasiveness of DNA methylation in the genome of A. mellifera provides fertile ground for future studies of phenotypic plasticity and genomic imprinting." @default.
• W2055742349 created "2016-06-24" @default.
• W2055742349 creator A5009792079 @default.
• W2055742349 creator A5031321464 @default.
• W2055742349 creator A5060589667 @default.
• W2055742349 creator A5084213906 @default.
• W2055742349 date "2009-07-07" @default.
• W2055742349 modified "2023-10-02" @default.
• W2055742349 title "DNA methylation is widespread and associated with differential gene expression in castes of the honeybee, <i>Apis mellifera</i>" @default.
• W2055742349 cites W1605917803 @default.
• W2055742349 cites W1944720880 @default.
• W2055742349 cites W1967841068 @default.
• W2055742349 cites W1968025102 @default.
• W2055742349 cites W1970042225 @default.
• W2055742349 cites W1980202457 @default.
• W2055742349 cites W2002497918 @default.
• W2055742349 cites W2019474060 @default.
• W2055742349 cites W2020995078 @default.
• W2055742349 cites W2026059246 @default.
• W2055742349 cites W2034105248 @default.
• W2055742349 cites W2037883697 @default.
• W2055742349 cites W2040849889 @default.
• W2055742349 cites W2041674913 @default.
• W2055742349 cites W2044401234 @default.
• W2055742349 cites W2057014463 @default.
• W2055742349 cites W2057917750 @default.
• W2055742349 cites W2064296221 @default.
• W2055742349 cites W2068588758 @default.
• W2055742349 cites W2072003932 @default.
• W2055742349 cites W2073157961 @default.
• W2055742349 cites W2074226183 @default.
• W2055742349 cites W2076729646 @default.
• W2055742349 cites W2076845646 @default.
• W2055742349 cites W2078028724 @default.
• W2055742349 cites W2085787388 @default.
• W2055742349 cites W2086327778 @default.
• W2055742349 cites W2086711900 @default.
• W2055742349 cites W2088156872 @default.
• W2055742349 cites W2091602444 @default.
• W2055742349 cites W2093958103 @default.
• W2055742349 cites W2094284586 @default.
• W2055742349 cites W2097233732 @default.
• W2055742349 cites W2099645775 @default.
• W2055742349 cites W2101831496 @default.
• W2055742349 cites W2102738091 @default.
• W2055742349 cites W2103017472 @default.
• W2055742349 cites W2114970231 @default.
• W2055742349 cites W2121417064 @default.
• W2055742349 cites W2123982853 @default.
• W2055742349 cites W2127938920 @default.
• W2055742349 cites W2137505881 @default.
• W2055742349 cites W2140097216 @default.
• W2055742349 cites W2147841227 @default.
• W2055742349 cites W2152497434 @default.
• W2055742349 cites W2153681829 @default.
• W2055742349 cites W2161224111 @default.
• W2055742349 cites W2162906882 @default.
• W2055742349 cites W2164659864 @default.
• W2055742349 cites W2166619901 @default.
• W2055742349 cites W2170700353 @default.
• W2055742349 cites W2171476395 @default.
• W2055742349 cites W4249273120 @default.
• W2055742349 cites W4378718562 @default.
• W2055742349 doi "https://doi.org/10.1073/pnas.0900301106" @default.
• W2055742349 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2708677" @default.
• W2055742349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19556545" @default.
• W2055742349 hasPublicationYear "2009" @default.
• W2055742349 type Work @default.
• W2055742349 sameAs 2055742349 @default.
• W2055742349 citedByCount "295" @default.
• W2055742349 countsByYear W20557423492012 @default.
• W2055742349 countsByYear W20557423492013 @default.
• W2055742349 countsByYear W20557423492014 @default.
• W2055742349 countsByYear W20557423492015 @default.
• W2055742349 countsByYear W20557423492016 @default.
• W2055742349 countsByYear W20557423492017 @default.
• W2055742349 countsByYear W20557423492018 @default.
• W2055742349 countsByYear W20557423492019 @default.
• W2055742349 countsByYear W20557423492020 @default.
• W2055742349 countsByYear W20557423492021 @default.
• W2055742349 countsByYear W20557423492022 @default.
• W2055742349 countsByYear W20557423492023 @default.
• W2055742349 crossrefType "journal-article" @default.
• W2055742349 hasAuthorship W2055742349A5009792079 @default.
• W2055742349 hasAuthorship W2055742349A5031321464 @default.
• W2055742349 hasAuthorship W2055742349A5060589667 @default.
• W2055742349 hasAuthorship W2055742349A5084213906 @default.
• W2055742349 hasBestOaLocation W20557423491 @default.
• W2055742349 hasConcept C104317684 @default.
• W2055742349 hasConcept C121912465 @default.
• W2055742349 hasConcept C140173407 @default.
• W2055742349 hasConcept C141231307 @default.
• W2055742349 hasConcept C150194340 @default.
• W2055742349 hasConcept C154253233 @default.
• W2055742349 hasConcept C163002167 @default.
• W2055742349 hasConcept C190727270 @default.
• W2055742349 hasConcept C201492766 @default.
• W2055742349 hasConcept C33288867 @default.

• next