FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055743669> ?p ?o ?g. }

• W2055743669 endingPage "1360" @default.
• W2055743669 startingPage "1348" @default.
• W2055743669 abstract "We previously reported that interleukin (IL)-6 deficiency potentiates trimethyltin (TMT)-induced convulsive neurotoxicity. The purpose in this study was to investigate the molecular mechanism by which cytokines affect TMT-induced cognitive impairment. To accomplish this, we examined hippocampal changes in Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling in relation to cholinergic parameters after TMT treatment in mice genetically deficient in IL-6 (IL-6−/−), tumor necrosis factor-α (TNF-α−/−), or interferon-γ (IFN-γ−/−). The IL-6−/− mice were the most susceptible to TMT-induced cognitive dysfunction and exhibited significant decreases in JAK2/STAT3 signaling and M1 muscarinic acetylcholine receptor (mAChR) expression, as well as other cholinergic parameters, compared with wild-type (WT) animals. Recombinant IL-6 protein (rIL-6) significantly attenuated these impairments in TMT-treated IL-6−/− mice, whereas an IL-6 receptor antibody potentiated these impairments in TMT-treated WT animals. Inhibition of JAK2 with AG490 or inhibition of cholinergic signaling with the M1 mAChR antagonist dicyclomine counteracted the attenuating effects of rIL-6 on phosphorylated extracellular signal-regulated kinase (ERK) expression, or on cognitive impairment in TMT-treated IL-6−/− mice. However, neither AG490 nor dicyclomine significantly attenuated effects of rIL-6 on acetylcholinesterase values. Our results suggest that activation of JAK2/STAT3 signaling and upregulation of the M1 mAChR are essential components of IL-6-mediated memory improvement against TMT toxicity." @default.
• W2055743669 created "2016-06-24" @default.
• W2055743669 creator A5002221770 @default.
• W2055743669 creator A5002587541 @default.
• W2055743669 creator A5008264631 @default.
• W2055743669 creator A5009725511 @default.
• W2055743669 creator A5010710813 @default.
• W2055743669 creator A5024744962 @default.
• W2055743669 creator A5037985631 @default.
• W2055743669 creator A5043861082 @default.
• W2055743669 creator A5055747865 @default.
• W2055743669 creator A5062200350 @default.
• W2055743669 creator A5065006809 @default.
• W2055743669 creator A5074484519 @default.
• W2055743669 date "2013-06-01" @default.
• W2055743669 modified "2023-10-14" @default.
• W2055743669 title "IL-6 attenuates trimethyltin-induced cognitive dysfunction via activation of JAK2/STAT3, M1 mAChR and ERK signaling network" @default.
• W2055743669 cites W1574091123 @default.
• W2055743669 cites W1964533091 @default.
• W2055743669 cites W1965604886 @default.
• W2055743669 cites W1970225606 @default.
• W2055743669 cites W1981558989 @default.
• W2055743669 cites W1983784282 @default.
• W2055743669 cites W1991942710 @default.
• W2055743669 cites W2001402754 @default.
• W2055743669 cites W2006653606 @default.
• W2055743669 cites W2006900071 @default.
• W2055743669 cites W2007501395 @default.
• W2055743669 cites W2008287057 @default.
• W2055743669 cites W2013889600 @default.
• W2055743669 cites W2017462073 @default.
• W2055743669 cites W2024783245 @default.
• W2055743669 cites W2026625969 @default.
• W2055743669 cites W2030593831 @default.
• W2055743669 cites W2032117526 @default.
• W2055743669 cites W2033792203 @default.
• W2055743669 cites W2034532812 @default.
• W2055743669 cites W2035879649 @default.
• W2055743669 cites W2040393829 @default.
• W2055743669 cites W2042396907 @default.
• W2055743669 cites W2045441677 @default.
• W2055743669 cites W2049272814 @default.
• W2055743669 cites W2055436920 @default.
• W2055743669 cites W2055463230 @default.
• W2055743669 cites W2056640669 @default.
• W2055743669 cites W2059759665 @default.
• W2055743669 cites W2064510187 @default.
• W2055743669 cites W2068078405 @default.
• W2055743669 cites W2068568993 @default.
• W2055743669 cites W2077627257 @default.
• W2055743669 cites W2078070194 @default.
• W2055743669 cites W2082304417 @default.
• W2055743669 cites W2085283151 @default.
• W2055743669 cites W2097740790 @default.
• W2055743669 cites W2099713879 @default.
• W2055743669 cites W2100663248 @default.
• W2055743669 cites W2115987064 @default.
• W2055743669 cites W2126795224 @default.
• W2055743669 cites W2130437557 @default.
• W2055743669 cites W2131619805 @default.
• W2055743669 cites W2135902389 @default.
• W2055743669 cites W2139834948 @default.
• W2055743669 cites W2168610467 @default.
• W2055743669 doi "https://doi.org/10.1016/j.cellsig.2013.02.017" @default.
• W2055743669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23499905" @default.
• W2055743669 hasPublicationYear "2013" @default.
• W2055743669 type Work @default.
• W2055743669 sameAs 2055743669 @default.
• W2055743669 citedByCount "33" @default.
• W2055743669 countsByYear W20557436692015 @default.
• W2055743669 countsByYear W20557436692016 @default.
• W2055743669 countsByYear W20557436692017 @default.
• W2055743669 countsByYear W20557436692018 @default.
• W2055743669 countsByYear W20557436692019 @default.
• W2055743669 countsByYear W20557436692020 @default.
• W2055743669 countsByYear W20557436692021 @default.
• W2055743669 countsByYear W20557436692022 @default.
• W2055743669 crossrefType "journal-article" @default.
• W2055743669 hasAuthorship W2055743669A5002221770 @default.
• W2055743669 hasAuthorship W2055743669A5002587541 @default.
• W2055743669 hasAuthorship W2055743669A5008264631 @default.
• W2055743669 hasAuthorship W2055743669A5009725511 @default.
• W2055743669 hasAuthorship W2055743669A5010710813 @default.
• W2055743669 hasAuthorship W2055743669A5024744962 @default.
• W2055743669 hasAuthorship W2055743669A5037985631 @default.
• W2055743669 hasAuthorship W2055743669A5043861082 @default.
• W2055743669 hasAuthorship W2055743669A5055747865 @default.
• W2055743669 hasAuthorship W2055743669A5062200350 @default.
• W2055743669 hasAuthorship W2055743669A5065006809 @default.
• W2055743669 hasAuthorship W2055743669A5074484519 @default.
• W2055743669 hasConcept C112392421 @default.
• W2055743669 hasConcept C126042315 @default.
• W2055743669 hasConcept C126322002 @default.
• W2055743669 hasConcept C134018914 @default.
• W2055743669 hasConcept C170493617 @default.
• W2055743669 hasConcept C171958077 @default.
• W2055743669 hasConcept C185592680 @default.
• W2055743669 hasConcept C22885893 @default.

• next