FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055748670> ?p ?o ?g. }

• W2055748670 endingPage "e100301" @default.
• W2055748670 startingPage "e100301" @default.
• W2055748670 abstract "Background Kyasanur Forest disease virus (KFDV) and Alkhurma hemorrhagic fever virus (AHFV) are closely related members of the Flavivirus genus and are important causes of human disease in India and the Arabian Peninsula, respectively. Despite high genetic similarity, the viruses have distinctly different host ranges and ecologies. Human cases of KFDV or AHFV develop a spectrum of disease syndromes ranging from liver pathology to neurologic disease. Case reports suggest KFDV is more commonly associated with hepatic and gastrointestinal manifestations whereas AHFV is more commonly associated with neurologic disease. Methodology/Principal Findings Inoculation of three immunocompetent laboratory mouse strains revealed that KFDV was consistently more lethal than AHFV. In subsequent studies utilizing C57BL/6J mice, we demonstrated that KFDV infection was associated with higher viral loads and significantly higher mortality. KFDV-infected mice rapidly developed more severe disease than AHFV-infected mice, as evidenced by significant abnormalities on clinical chemistry panels and more severe pathology in the brain and gastrointestinal tract. Conclusions/Significance Infections of C57BL/6J mice with KFDV or AHFV resulted in clinical disease syndromes that closely approximate the diseases seen in human cases. Despite high genetic similarity, there were clear differences in survival, viral kinetics, clinical chemistry data and histology. These results suggest that distinct mouse models for AHFV and KFDV are necessary in order to gain a better understanding of the unique pathogenesis of each virus, as well as to provide platforms for testing promising vaccines and therapeutics." @default.
• W2055748670 created "2016-06-24" @default.
• W2055748670 creator A5014946505 @default.
• W2055748670 creator A5025372825 @default.
• W2055748670 creator A5034664089 @default.
• W2055748670 creator A5063653289 @default.
• W2055748670 creator A5076223460 @default.
• W2055748670 date "2014-06-20" @default.
• W2055748670 modified "2023-09-27" @default.
• W2055748670 title "Kyasanur Forest Disease Virus Infection in Mice Is Associated with Higher Morbidity and Mortality than Infection with the Closely Related Alkhurma Hemorrhagic Fever Virus" @default.
• W2055748670 cites W1963536027 @default.
• W2055748670 cites W1963541049 @default.
• W2055748670 cites W1980750214 @default.
• W2055748670 cites W1994907449 @default.
• W2055748670 cites W2002270753 @default.
• W2055748670 cites W2016222582 @default.
• W2055748670 cites W2028225274 @default.
• W2055748670 cites W2047882003 @default.
• W2055748670 cites W2091648107 @default.
• W2055748670 cites W2091800573 @default.
• W2055748670 cites W2116022661 @default.
• W2055748670 cites W2119812286 @default.
• W2055748670 cites W2138472991 @default.
• W2055748670 cites W2140326543 @default.
• W2055748670 cites W2148377365 @default.
• W2055748670 cites W2152290398 @default.
• W2055748670 cites W2158373262 @default.
• W2055748670 cites W2160278500 @default.
• W2055748670 cites W2415989275 @default.
• W2055748670 doi "https://doi.org/10.1371/journal.pone.0100301" @default.
• W2055748670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4065072" @default.
• W2055748670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24950196" @default.
• W2055748670 hasPublicationYear "2014" @default.
• W2055748670 type Work @default.
• W2055748670 sameAs 2055748670 @default.
• W2055748670 citedByCount "20" @default.
• W2055748670 countsByYear W20557486702016 @default.
• W2055748670 countsByYear W20557486702017 @default.
• W2055748670 countsByYear W20557486702018 @default.
• W2055748670 countsByYear W20557486702019 @default.
• W2055748670 countsByYear W20557486702020 @default.
• W2055748670 countsByYear W20557486702021 @default.
• W2055748670 countsByYear W20557486702022 @default.
• W2055748670 countsByYear W20557486702023 @default.
• W2055748670 crossrefType "journal-article" @default.
• W2055748670 hasAuthorship W2055748670A5014946505 @default.
• W2055748670 hasAuthorship W2055748670A5025372825 @default.
• W2055748670 hasAuthorship W2055748670A5034664089 @default.
• W2055748670 hasAuthorship W2055748670A5063653289 @default.
• W2055748670 hasAuthorship W2055748670A5076223460 @default.
• W2055748670 hasBestOaLocation W20557486701 @default.
• W2055748670 hasConcept C142724271 @default.
• W2055748670 hasConcept C159047783 @default.
• W2055748670 hasConcept C203014093 @default.
• W2055748670 hasConcept C2522874641 @default.
• W2055748670 hasConcept C2777510210 @default.
• W2055748670 hasConcept C2779134260 @default.
• W2055748670 hasConcept C2780512811 @default.
• W2055748670 hasConcept C2780568436 @default.
• W2055748670 hasConcept C2780727368 @default.
• W2055748670 hasConcept C2780942790 @default.
• W2055748670 hasConcept C55493867 @default.
• W2055748670 hasConcept C71924100 @default.
• W2055748670 hasConcept C86803240 @default.
• W2055748670 hasConceptScore W2055748670C142724271 @default.
• W2055748670 hasConceptScore W2055748670C159047783 @default.
• W2055748670 hasConceptScore W2055748670C203014093 @default.
• W2055748670 hasConceptScore W2055748670C2522874641 @default.
• W2055748670 hasConceptScore W2055748670C2777510210 @default.
• W2055748670 hasConceptScore W2055748670C2779134260 @default.
• W2055748670 hasConceptScore W2055748670C2780512811 @default.
• W2055748670 hasConceptScore W2055748670C2780568436 @default.
• W2055748670 hasConceptScore W2055748670C2780727368 @default.
• W2055748670 hasConceptScore W2055748670C2780942790 @default.
• W2055748670 hasConceptScore W2055748670C55493867 @default.
• W2055748670 hasConceptScore W2055748670C71924100 @default.
• W2055748670 hasConceptScore W2055748670C86803240 @default.
• W2055748670 hasIssue "6" @default.
• W2055748670 hasLocation W20557486701 @default.
• W2055748670 hasLocation W20557486702 @default.
• W2055748670 hasLocation W20557486703 @default.
• W2055748670 hasLocation W20557486704 @default.
• W2055748670 hasLocation W20557486705 @default.
• W2055748670 hasOpenAccess W2055748670 @default.
• W2055748670 hasPrimaryLocation W20557486701 @default.
• W2055748670 hasRelatedWork W123797257 @default.
• W2055748670 hasRelatedWork W1968644509 @default.
• W2055748670 hasRelatedWork W1998108299 @default.
• W2055748670 hasRelatedWork W2042506043 @default.
• W2055748670 hasRelatedWork W2094230406 @default.
• W2055748670 hasRelatedWork W2098030187 @default.
• W2055748670 hasRelatedWork W2105597814 @default.
• W2055748670 hasRelatedWork W2111868491 @default.
• W2055748670 hasRelatedWork W2133993169 @default.
• W2055748670 hasRelatedWork W2148633206 @default.
• W2055748670 hasVolume "9" @default.
• W2055748670 isParatext "false" @default.
• W2055748670 isRetracted "false" @default.

• next