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• W2055751544 startingPage "385" @default.
• W2055751544 abstract "Awareness is increasing that progesterone signalling via the progesterone receptor (PR) has important roles in breast biology and breast cancer. Understanding more about this pathway may lead to new therapeutic and preventive options for breast cancer. Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase inhibitors in breast cancer treatment, oestrogens have long received the most attention. Early progesterone receptor (PR) antagonists, however, were dismissed because of severe side effects, but awareness is now increasing that progesterone is an important hormone in breast cancer. Oestrogen receptor-α (ERα) signalling and PR signalling have distinct roles in normal mammary gland biology in mice; both ERα and PR delegate many of their biological functions to distinct paracrine mediators. If the findings in the mouse model translate to humans, new preventive and therapeutic perspectives might open up." @default.
• W2055751544 created "2016-06-24" @default.
• W2055751544 creator A5074367632 @default.
• W2055751544 date "2013-05-24" @default.
• W2055751544 modified "2023-10-13" @default.
• W2055751544 title "Progesterone signalling in breast cancer: a neglected hormone coming into the limelight" @default.
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• W2055751544 doi "https://doi.org/10.1038/nrc3518" @default.
• W2055751544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23702927" @default.
• W2055751544 hasPublicationYear "2013" @default.
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