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- W2055753359 abstract "The interaction of [125I]spiperone and [3H]spiperone with CHAPS solubilized preparations of rat striatal tissue has been compared. Only about 15% of [125I]spiperone binding was displaced by sulpiride compared with about 67% of [3H]spiperone binding. In the presence of (+)-butaclamol the displacement of [125I]spiperone was twice that found with sulpiride suggesting an interaction with sites other than D-2 receptors. The specific binding of [125I]spiperone was not saturable within the maximum concentration range that could be employed and its affinity for soluble preparations was far lower than that of [3H]spiperone. Despite its very high specific activity [125I]spiperone offers no advantage over [3H]spiperone in the identification of dopamine receptors in soluble tissue preparations." @default.
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- W2055753359 date "1986-05-01" @default.
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- W2055753359 title "[125I] Spiperone is not a useful ligand for studying the CHAPS solubilized dopamine D-2 receptor from rat striatum" @default.
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- W2055753359 doi "https://doi.org/10.1111/j.2042-7158.1986.tb04601.x" @default.
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