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- W2055753618 abstract "We examined the effects of dietary nucleotides on the immune response balance in two subtypes of T helper cells, type 1 (Th1) and type 2 (Th2) cells. In experiment 1, BALB/c mice were maintained on a nucleotide-free diet (NT(−) diet) or the NT(−) diet supplemented with dietary nucleotides (NT(+) diet) from 4 weeks prior to mating and throughout the experiments. The second generations of these mice (F1) were maintained on the same diet as the respective dams. Male F1-generation mice were used to determine the serum immunoglobulin levels. The serum IgE levels were significantly decreased in mice fed the NT(+) diet (p <0.05) compared with ones fed the NT(−) diet. The serum IgG1 and IgG2a levels were not significantly different between the two dietary groups. However, the IgG1:IgG2a level ratio was significantly decreased in mice fed the NT(+) diet (p <0.05). In experiment 2, BALB/c weanling mice were placed on the NT(−) diet or NT(+) diet for 10 weeks. The production of splenic interleukin-4, a cytokine produced by Th2, was decreased in mice fed the NT(+) diet compared with ones fed the NT(−) diet. On the other hand, the production of splenic interferon - γ, a cytokine produced by Th1, was increased in mice fed the NT(+) diet. These results suggest that dietary nucleotides may up-regulate the Th1 immune response in systemic immunity. © 1997 Elsevier Science Inc." @default.
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- W2055753618 date "1997-07-01" @default.
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- W2055753618 title "EFFECTS OF DIETARY NUCLEOTIDES ON SERUM ANTIBODY AND SPLENIC CYTOKINE PRODUCTION IN MICE" @default.
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- W2055753618 doi "https://doi.org/10.1016/s0271-5317(97)00086-9" @default.
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