Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055764576> ?p ?o ?g. }
- W2055764576 endingPage "983" @default.
- W2055764576 startingPage "969" @default.
- W2055764576 abstract "Embedded in the nuclear envelope, nuclear pore complexes (NPCs) not only regulate nuclear transport but also interface with transcriptionally active euchromatin, largely silenced heterochromatin, as well as the boundaries between these regions. It is unclear what functional role NPCs play in establishing or maintaining these distinct chromatin domains. We report that the yeast NPC protein Nup170p interacts with regions of the genome that contain ribosomal protein and subtelomeric genes, where it functions in nucleosome positioning and as a repressor of transcription. We show that the role of Nup170p in subtelomeric gene silencing is linked to its association with the RSC chromatin-remodeling complex and the silencing factor Sir4p, and that the binding of Nup170p and Sir4p to subtelomeric chromatin is cooperative and necessary for the association of telomeres with the nuclear envelope. Our results establish the NPC as an active participant in silencing and the formation of peripheral heterochromatin." @default.
- W2055764576 created "2016-06-24" @default.
- W2055764576 creator A5003978275 @default.
- W2055764576 creator A5033389433 @default.
- W2055764576 creator A5046658391 @default.
- W2055764576 creator A5052551167 @default.
- W2055764576 creator A5062802526 @default.
- W2055764576 creator A5081685880 @default.
- W2055764576 creator A5087116882 @default.
- W2055764576 date "2013-02-01" @default.
- W2055764576 modified "2023-09-30" @default.
- W2055764576 title "A Role for the Nucleoporin Nup170p in Chromatin Structure and Gene Silencing" @default.
- W2055764576 cites W1483456869 @default.
- W2055764576 cites W1528082486 @default.
- W2055764576 cites W1559808711 @default.
- W2055764576 cites W1898015186 @default.
- W2055764576 cites W1963996414 @default.
- W2055764576 cites W1966072209 @default.
- W2055764576 cites W1969228261 @default.
- W2055764576 cites W1969901238 @default.
- W2055764576 cites W1971799079 @default.
- W2055764576 cites W1973998137 @default.
- W2055764576 cites W1977780474 @default.
- W2055764576 cites W1979244573 @default.
- W2055764576 cites W1980835191 @default.
- W2055764576 cites W1983277632 @default.
- W2055764576 cites W1989854142 @default.
- W2055764576 cites W1990186602 @default.
- W2055764576 cites W1990396035 @default.
- W2055764576 cites W1994598776 @default.
- W2055764576 cites W1996364283 @default.
- W2055764576 cites W1997530113 @default.
- W2055764576 cites W2004995654 @default.
- W2055764576 cites W2011717438 @default.
- W2055764576 cites W2013970469 @default.
- W2055764576 cites W2014119967 @default.
- W2055764576 cites W2015881243 @default.
- W2055764576 cites W2017550851 @default.
- W2055764576 cites W2019057425 @default.
- W2055764576 cites W2019655981 @default.
- W2055764576 cites W2019923915 @default.
- W2055764576 cites W2025744458 @default.
- W2055764576 cites W2029388127 @default.
- W2055764576 cites W2031098287 @default.
- W2055764576 cites W2033218445 @default.
- W2055764576 cites W2038486012 @default.
- W2055764576 cites W2043481575 @default.
- W2055764576 cites W2050239959 @default.
- W2055764576 cites W2055522522 @default.
- W2055764576 cites W2056236390 @default.
- W2055764576 cites W2060403740 @default.
- W2055764576 cites W2060599714 @default.
- W2055764576 cites W2061592942 @default.
- W2055764576 cites W2063989075 @default.
- W2055764576 cites W2073080554 @default.
- W2055764576 cites W2087975988 @default.
- W2055764576 cites W2091642705 @default.
- W2055764576 cites W2096324459 @default.
- W2055764576 cites W2097982583 @default.
- W2055764576 cites W2100045646 @default.
- W2055764576 cites W2101917229 @default.
- W2055764576 cites W2105487944 @default.
- W2055764576 cites W2106466938 @default.
- W2055764576 cites W2114389399 @default.
- W2055764576 cites W2114803986 @default.
- W2055764576 cites W2115734610 @default.
- W2055764576 cites W2116988943 @default.
- W2055764576 cites W2119465972 @default.
- W2055764576 cites W2124950472 @default.
- W2055764576 cites W2127073167 @default.
- W2055764576 cites W2133102806 @default.
- W2055764576 cites W2133201628 @default.
- W2055764576 cites W2138028003 @default.
- W2055764576 cites W2138292935 @default.
- W2055764576 cites W2140948740 @default.
- W2055764576 cites W2141339789 @default.
- W2055764576 cites W2143432207 @default.
- W2055764576 cites W2145345456 @default.
- W2055764576 cites W2146503498 @default.
- W2055764576 cites W2146666887 @default.
- W2055764576 cites W2147635825 @default.
- W2055764576 cites W2149327250 @default.
- W2055764576 cites W2149438959 @default.
- W2055764576 cites W2154046032 @default.
- W2055764576 cites W2156315323 @default.
- W2055764576 cites W2158804744 @default.
- W2055764576 cites W2159460045 @default.
- W2055764576 cites W2159675211 @default.
- W2055764576 cites W2163485494 @default.
- W2055764576 cites W2163504716 @default.
- W2055764576 cites W2164565059 @default.
- W2055764576 cites W2165913063 @default.
- W2055764576 cites W2166767358 @default.
- W2055764576 cites W2166786710 @default.
- W2055764576 cites W2168955594 @default.
- W2055764576 cites W2169113150 @default.
- W2055764576 cites W2169333620 @default.
- W2055764576 cites W2171432823 @default.