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- W2055771353 abstract "The central lens fibers of genetically microphthalmic mice (Eye lens obsolescence, Elo) continue to necrose from the early stage of lens development, whereas morphological defects are not observed in the lens epithelium, equatorial zone of the lens and the other ocular tissues. We attempted to determine whether or not this occurrence in the lens of Elo mice was related to extraocular factors such as nutrition and secondly if a possible mal-synthesis of γ-crystallin could be involved. The first problem was investigated using organ cultures of the eye rudiments excised from day 10 and day 11 embryos. The typical Elo lens developed on the artificial nutrients, indicating that pathogenesis of the Elo is independent of the extraocular environment. The second problem was investigated using immunohistochemistry. The synthesis of γ-crystallin in the lens of the Elo and the normal was similar, thereby suggesting that the necrotic process in the lens fibers of the Elo is not due to defects in γ-crystallin synthesis." @default.
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- W2055771353 date "1980-12-01" @default.
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- W2055771353 title "Organ culture and immunohistochemistry of the genetically malformed lens, in Eye lens obsolescence, Elo, of the mouse" @default.
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- W2055771353 doi "https://doi.org/10.1016/s0014-4835(80)80052-2" @default.
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