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• W2055778868 abstract "A novel opiate antagonist, Nalmefene (0.5 or 5.0 mg/kg/day) was tested for its ability to modulate regional brain glucose uptake rates in genetically diabetic C57BL/KsJ mice, which normally exhibit a depressed CNS carbohydrate metabolism relative to age-matched controls. Daily Nalmefene treatment had no effect on circulating blood glucose levels in either normal or diabetic mice over a 7-week test period. However, all brain regions, except the olfactory bulbs, exhibited normalized glucose uptake rates in diabetic mice relative to controls. These data suggest a role for opiate antagonists in the modulation of CNS glucose metabolism during hyperglycemic states." @default.
• W2055778868 created "2016-06-24" @default.
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• W2055778868 date "1988-04-01" @default.
• W2055778868 modified "2023-10-16" @default.
• W2055778868 title "Regional brain glucose uptake in genetically diabetic C57BL/KsJ mice: modulation by the opiate antagonist, Nalmefene" @default.
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• W2055778868 doi "https://doi.org/10.1016/0006-8993(88)91188-2" @default.
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