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- W2055789048 abstract "The generation of germline gene mutations in mice has been an invaluable tool for experimental biology. However, studying immune responses that develop in the absence of a specific protein that could alter thymic selection complicates experimental interpretations. We observed that CD8+ T cells from Stat6−/− mice displayed “autoreactivity” to STAT6-expressing cells, associated with specific STAT6 peptides binding to MHC class I molecules. These results suggest caution in interpreting experiments where STAT6-expressing cells are transferred into Stat6−/− mice, or where adoptive transfer of Stat6−/− lymphocytes is performed. Our results further highlight additional considerations when studying immune responses involving cell transfer into gene-deficient mice." @default.
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- W2055789048 date "2013-04-01" @default.
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- W2055789048 title "Anti-STAT6 CTL activity inStat6−/−mice" @default.
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- W2055789048 doi "https://doi.org/10.4161/jkst.24554" @default.
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