Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055789724> ?p ?o ?g. }
- W2055789724 endingPage "40" @default.
- W2055789724 startingPage "35" @default.
- W2055789724 abstract "Previous data obtained in vivo and in vitro suggest that both prostaglandins (PGs) and catecholamines may have a role in promoting hepatocyte proliferation, and PGE2 and PGFF2α have also been implicated as mediators of the mitogenic actions of epidermal growth factor (EGF) (and transforming growth factor alpha [TGFα]). We have studied the effects of PGs and norepinephrine on DNA synthesis in serum-free primary cultures of rat hepatocytes, and compared the PG effects with those of norepinephrine. PGE2, PGF2α, PGD2, and the synthetic analog dimethyl-PGE2 markedly enhanced the DNA synthesis. A more quantitative analysis of the effects of PGE2 and PGF2α on the DNA synthesis, in the presence and absence of EGF, indicated that these PGs interacted in an essentially multiplicative manner with the effect of EGF. The effects of PGE2 and PGF2α showed almost complete additivity with the stimulation of DNA synthesis produced by maximally effective concentrations of norepinephrine. The data suggest (a) that PGE2 and PGF2α facilitate and synergize with, rather than mediate, the actions of EGF in hepatocytes, and (b) that this effect of the PGs occurs by mechanisms that are at least partly distinct from those of norepinephrine. © 1994 wiley-Liss, Inc." @default.
- W2055789724 created "2016-06-24" @default.
- W2055789724 creator A5004806760 @default.
- W2055789724 creator A5005744366 @default.
- W2055789724 creator A5044057191 @default.
- W2055789724 creator A5048774800 @default.
- W2055789724 date "1994-04-01" @default.
- W2055789724 modified "2023-09-27" @default.
- W2055789724 title "Stimulation of hepatocyte DNA synthesis by prostaglandin E2 and prostaglandin F2? additivity with the effect of norepinephrine, and synergism with epidermal growth factor" @default.
- W2055789724 cites W1490154674 @default.
- W2055789724 cites W1512819401 @default.
- W2055789724 cites W1563645938 @default.
- W2055789724 cites W1775749144 @default.
- W2055789724 cites W1856590789 @default.
- W2055789724 cites W1877831411 @default.
- W2055789724 cites W1919800789 @default.
- W2055789724 cites W1968775911 @default.
- W2055789724 cites W1973563561 @default.
- W2055789724 cites W1989603835 @default.
- W2055789724 cites W1989888122 @default.
- W2055789724 cites W2004183888 @default.
- W2055789724 cites W2010880467 @default.
- W2055789724 cites W2014662592 @default.
- W2055789724 cites W2022104437 @default.
- W2055789724 cites W2033261145 @default.
- W2055789724 cites W2035760808 @default.
- W2055789724 cites W2040061320 @default.
- W2055789724 cites W2040692661 @default.
- W2055789724 cites W2042040398 @default.
- W2055789724 cites W2043755296 @default.
- W2055789724 cites W2045434282 @default.
- W2055789724 cites W2056132372 @default.
- W2055789724 cites W2068629141 @default.
- W2055789724 cites W2072482644 @default.
- W2055789724 cites W2072492234 @default.
- W2055789724 cites W2073693752 @default.
- W2055789724 cites W2085145054 @default.
- W2055789724 cites W2088808384 @default.
- W2055789724 cites W2093198515 @default.
- W2055789724 cites W2093424402 @default.
- W2055789724 cites W2106988040 @default.
- W2055789724 cites W2119039585 @default.
- W2055789724 cites W2123203140 @default.
- W2055789724 cites W2155798958 @default.
- W2055789724 cites W2160385278 @default.
- W2055789724 cites W2164482844 @default.
- W2055789724 cites W2166156764 @default.
- W2055789724 cites W2167859431 @default.
- W2055789724 cites W2273397077 @default.
- W2055789724 cites W2342856850 @default.
- W2055789724 cites W4256244076 @default.
- W2055789724 doi "https://doi.org/10.1002/jcp.1041590106" @default.
- W2055789724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8138589" @default.
- W2055789724 hasPublicationYear "1994" @default.
- W2055789724 type Work @default.
- W2055789724 sameAs 2055789724 @default.
- W2055789724 citedByCount "55" @default.
- W2055789724 countsByYear W20557897242012 @default.
- W2055789724 countsByYear W20557897242013 @default.
- W2055789724 countsByYear W20557897242014 @default.
- W2055789724 countsByYear W20557897242015 @default.
- W2055789724 countsByYear W20557897242016 @default.
- W2055789724 countsByYear W20557897242017 @default.
- W2055789724 countsByYear W20557897242018 @default.
- W2055789724 countsByYear W20557897242023 @default.
- W2055789724 crossrefType "journal-article" @default.
- W2055789724 hasAuthorship W2055789724A5004806760 @default.
- W2055789724 hasAuthorship W2055789724A5005744366 @default.
- W2055789724 hasAuthorship W2055789724A5044057191 @default.
- W2055789724 hasAuthorship W2055789724A5048774800 @default.
- W2055789724 hasConcept C126322002 @default.
- W2055789724 hasConcept C134018914 @default.
- W2055789724 hasConcept C150903083 @default.
- W2055789724 hasConcept C170493617 @default.
- W2055789724 hasConcept C185592680 @default.
- W2055789724 hasConcept C202751555 @default.
- W2055789724 hasConcept C207001950 @default.
- W2055789724 hasConcept C24998067 @default.
- W2055789724 hasConcept C2776200302 @default.
- W2055789724 hasConcept C2776362946 @default.
- W2055789724 hasConcept C2777198256 @default.
- W2055789724 hasConcept C2777956040 @default.
- W2055789724 hasConcept C2778514916 @default.
- W2055789724 hasConcept C2780664492 @default.
- W2055789724 hasConcept C513476851 @default.
- W2055789724 hasConcept C55493867 @default.
- W2055789724 hasConcept C64241487 @default.
- W2055789724 hasConcept C71924100 @default.
- W2055789724 hasConcept C86803240 @default.
- W2055789724 hasConceptScore W2055789724C126322002 @default.
- W2055789724 hasConceptScore W2055789724C134018914 @default.
- W2055789724 hasConceptScore W2055789724C150903083 @default.
- W2055789724 hasConceptScore W2055789724C170493617 @default.
- W2055789724 hasConceptScore W2055789724C185592680 @default.
- W2055789724 hasConceptScore W2055789724C202751555 @default.
- W2055789724 hasConceptScore W2055789724C207001950 @default.
- W2055789724 hasConceptScore W2055789724C24998067 @default.
- W2055789724 hasConceptScore W2055789724C2776200302 @default.