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- W2055793934 abstract "ObjectiveCompare pregnancy loss patterns in fresh transfer with low, moderate, and high levels of pre-ovulatory progesterone (P4) against frozen-thawed cycles without controlled ovarian stimulation (COS).DesignRetrospective cohort study.Materials and MethodsInclusion criteria specified pregnancy after blastocyst transfer in patients <35 years of age or else using oocyte donors <35 years of age. Fresh non-donor cycles were stratified according to pre-trigger P4 level. Pregnancies in frozen-thawed non-donor cycles served as controls. Biochemical pregnancies were lost after rising hCG titers. Ectopic pregnancies included extrauterine pregnancies and pregnancies of unknown location treated as ectopic. Spontaneous abortions (SAB) were lost intrauterine pregnancies. Due to multiple comparisons, P-values <0.01 were significant (Bonferroni correction).ResultsCompared to the control (frozen-thawed) group, fresh cycle pregnancies had increased biochemical pregnancy loss and ectopic pregnancy rates. Pregnancies following moderate P4 level (1.0 to 1.5 ng/mL) had greater biochemical pregnancy loss rate than the control group. Pregnancies following P4≥1.5 ng/mL had greater biochemical pregnancy loss and ectopic pregnancy rates than controls. Oocyte donation cycles had similar pattern of pregnancy loss as controls.ConclusionTable 1All fresh non-donor transfersFresh, P4<1.0Fresh, 1.0≤P4<1.5Fresh, P4≥1.5Frozen-thawed (control group)Oocyte DonationAll pregnancies597246203148406240Biochemical pregnancies (%)99 (16.6) *31 (12.6)36 (17.7) *32 (21.6) *31 (7.6)17 (7.1)Ectopic pregnancies (%)25 (4.2) *5 (2.0)7 (3.4)13 (8.8) *3 (0.7)0 (0.0)Intra-uterine pregnancies473210160103372223SAB (%)59 (12.5)26 (12.4)23 (14.4)10 (9.7)46 (12.4)31 (13.9)P4= pre-ovulatory serum progesterone level (ng/mL). * = significantly different from control group (P<0.01). Open table in a new tab ObjectiveCompare pregnancy loss patterns in fresh transfer with low, moderate, and high levels of pre-ovulatory progesterone (P4) against frozen-thawed cycles without controlled ovarian stimulation (COS). Compare pregnancy loss patterns in fresh transfer with low, moderate, and high levels of pre-ovulatory progesterone (P4) against frozen-thawed cycles without controlled ovarian stimulation (COS). DesignRetrospective cohort study. Retrospective cohort study. Materials and MethodsInclusion criteria specified pregnancy after blastocyst transfer in patients <35 years of age or else using oocyte donors <35 years of age. Fresh non-donor cycles were stratified according to pre-trigger P4 level. Pregnancies in frozen-thawed non-donor cycles served as controls. Biochemical pregnancies were lost after rising hCG titers. Ectopic pregnancies included extrauterine pregnancies and pregnancies of unknown location treated as ectopic. Spontaneous abortions (SAB) were lost intrauterine pregnancies. Due to multiple comparisons, P-values <0.01 were significant (Bonferroni correction). Inclusion criteria specified pregnancy after blastocyst transfer in patients <35 years of age or else using oocyte donors <35 years of age. Fresh non-donor cycles were stratified according to pre-trigger P4 level. Pregnancies in frozen-thawed non-donor cycles served as controls. Biochemical pregnancies were lost after rising hCG titers. Ectopic pregnancies included extrauterine pregnancies and pregnancies of unknown location treated as ectopic. Spontaneous abortions (SAB) were lost intrauterine pregnancies. Due to multiple comparisons, P-values <0.01 were significant (Bonferroni correction). ResultsCompared to the control (frozen-thawed) group, fresh cycle pregnancies had increased biochemical pregnancy loss and ectopic pregnancy rates. Pregnancies following moderate P4 level (1.0 to 1.5 ng/mL) had greater biochemical pregnancy loss rate than the control group. Pregnancies following P4≥1.5 ng/mL had greater biochemical pregnancy loss and ectopic pregnancy rates than controls. Oocyte donation cycles had similar pattern of pregnancy loss as controls. Compared to the control (frozen-thawed) group, fresh cycle pregnancies had increased biochemical pregnancy loss and ectopic pregnancy rates. Pregnancies following moderate P4 level (1.0 to 1.5 ng/mL) had greater biochemical pregnancy loss rate than the control group. Pregnancies following P4≥1.5 ng/mL had greater biochemical pregnancy loss and ectopic pregnancy rates than controls. Oocyte donation cycles had similar pattern of pregnancy loss as controls. ConclusionTable 1All fresh non-donor transfersFresh, P4<1.0Fresh, 1.0≤P4<1.5Fresh, P4≥1.5Frozen-thawed (control group)Oocyte DonationAll pregnancies597246203148406240Biochemical pregnancies (%)99 (16.6) *31 (12.6)36 (17.7) *32 (21.6) *31 (7.6)17 (7.1)Ectopic pregnancies (%)25 (4.2) *5 (2.0)7 (3.4)13 (8.8) *3 (0.7)0 (0.0)Intra-uterine pregnancies473210160103372223SAB (%)59 (12.5)26 (12.4)23 (14.4)10 (9.7)46 (12.4)31 (13.9)P4= pre-ovulatory serum progesterone level (ng/mL). * = significantly different from control group (P<0.01). Open table in a new tab P4= pre-ovulatory serum progesterone level (ng/mL). * = significantly different from control group (P<0.01)." @default.
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- W2055793934 date "2013-09-01" @default.
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- W2055793934 title "Pattern of pregnancy loss is determined by exposure to ovarian stimulation and pre-ovulatory progesterone" @default.
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