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• W2055801062 abstract "In a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein--Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All of the compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Calocoumarin-A (5) showed more potent activity than any of the other compounds tested. Furthermore, calocoumarin-A (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The results of the present investigation indicate that some of these 4-phenylcoumarins might be valuable as potential cancer chemopreventive agents (anti-tumor-promoters)." @default.
• W2055801062 created "2016-06-24" @default.
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• W2055801062 date "2001-08-01" @default.
• W2055801062 modified "2023-10-06" @default.
• W2055801062 title "Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum" @default.
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• W2055801062 doi "https://doi.org/10.1016/s0304-3835(01)00521-3" @default.
• W2055801062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11410320" @default.
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