Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055803040> ?p ?o ?g. }
- W2055803040 endingPage "319" @default.
- W2055803040 startingPage "305" @default.
- W2055803040 abstract "The relationship of age to the circadian rhythms of melatonin and cortisol was investigated in 44 men and 27 women (age range 19-89 years). Subjects were physically and psychiatrically normal. Four hourly serial blood samples were drawn from 8:00 AM until 8:00 AM the next day, with additional samples at 10:00 PM and 2:00 AM. The indoor illumination was restricted to 300 lux during day and 50 lux during the night. Plasma melatonin and cortisol were estimated by radioimmunoassay. Results show that the means of melatonin and cortisol values decreased significantly with age when the subjects were divided into three age groups, i.e., 19-25 years, 42-65 years, and 66-89 years. They also showed a significant negative correlation with age. The acrophases of the two hormonal rhythms, however, showed different relationships to age. The acrophase of melatonin rhythm showed a positive correlation with age (r = 0.38, p less than 0.001), and cortisol showed a negative correlation with age (r = -0.56, p greater than 0.001). It is suggested that this may indicate a weakened responsiveness of the circadian system in the elderly to the day-night cycle and an altered relationship between the pacemakers driving melatonin and cortisol circadian rhythms. This may thus represent a biomarker for the intrinsic process of the aging of the brain." @default.
- W2055803040 created "2016-06-24" @default.
- W2055803040 creator A5005797929 @default.
- W2055803040 creator A5033459710 @default.
- W2055803040 creator A5055183128 @default.
- W2055803040 creator A5059560700 @default.
- W2055803040 creator A5068119488 @default.
- W2055803040 creator A5070229422 @default.
- W2055803040 creator A5079969814 @default.
- W2055803040 date "1989-02-01" @default.
- W2055803040 modified "2023-10-03" @default.
- W2055803040 title "Circadian rhythms of melatonin and cortisol in aging" @default.
- W2055803040 cites W1569552610 @default.
- W2055803040 cites W1584040668 @default.
- W2055803040 cites W1965397317 @default.
- W2055803040 cites W1965543679 @default.
- W2055803040 cites W1965709853 @default.
- W2055803040 cites W1970446877 @default.
- W2055803040 cites W1972651925 @default.
- W2055803040 cites W1977143695 @default.
- W2055803040 cites W1979395732 @default.
- W2055803040 cites W1983706883 @default.
- W2055803040 cites W1988004297 @default.
- W2055803040 cites W1988410225 @default.
- W2055803040 cites W1988511252 @default.
- W2055803040 cites W1995833286 @default.
- W2055803040 cites W2003252763 @default.
- W2055803040 cites W2008111036 @default.
- W2055803040 cites W2013761553 @default.
- W2055803040 cites W2017475699 @default.
- W2055803040 cites W2026156430 @default.
- W2055803040 cites W2029707480 @default.
- W2055803040 cites W2030676166 @default.
- W2055803040 cites W2032644259 @default.
- W2055803040 cites W2041183107 @default.
- W2055803040 cites W2044510143 @default.
- W2055803040 cites W2048489440 @default.
- W2055803040 cites W2051651703 @default.
- W2055803040 cites W2051691258 @default.
- W2055803040 cites W2053597117 @default.
- W2055803040 cites W2056122458 @default.
- W2055803040 cites W2068440136 @default.
- W2055803040 cites W2071702639 @default.
- W2055803040 cites W2077572353 @default.
- W2055803040 cites W2078327968 @default.
- W2055803040 cites W2080035729 @default.
- W2055803040 cites W2091342760 @default.
- W2055803040 cites W2124540184 @default.
- W2055803040 cites W2134199290 @default.
- W2055803040 cites W2141516733 @default.
- W2055803040 cites W2154216062 @default.
- W2055803040 cites W2166347315 @default.
- W2055803040 cites W2318348546 @default.
- W2055803040 cites W2325265010 @default.
- W2055803040 cites W4362217318 @default.
- W2055803040 doi "https://doi.org/10.1016/0006-3223(89)90178-9" @default.
- W2055803040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2914154" @default.
- W2055803040 hasPublicationYear "1989" @default.
- W2055803040 type Work @default.
- W2055803040 sameAs 2055803040 @default.
- W2055803040 citedByCount "229" @default.
- W2055803040 countsByYear W20558030402012 @default.
- W2055803040 countsByYear W20558030402013 @default.
- W2055803040 countsByYear W20558030402014 @default.
- W2055803040 countsByYear W20558030402015 @default.
- W2055803040 countsByYear W20558030402016 @default.
- W2055803040 countsByYear W20558030402017 @default.
- W2055803040 countsByYear W20558030402018 @default.
- W2055803040 countsByYear W20558030402019 @default.
- W2055803040 countsByYear W20558030402020 @default.
- W2055803040 countsByYear W20558030402021 @default.
- W2055803040 countsByYear W20558030402022 @default.
- W2055803040 countsByYear W20558030402023 @default.
- W2055803040 crossrefType "journal-article" @default.
- W2055803040 hasAuthorship W2055803040A5005797929 @default.
- W2055803040 hasAuthorship W2055803040A5033459710 @default.
- W2055803040 hasAuthorship W2055803040A5055183128 @default.
- W2055803040 hasAuthorship W2055803040A5059560700 @default.
- W2055803040 hasAuthorship W2055803040A5068119488 @default.
- W2055803040 hasAuthorship W2055803040A5070229422 @default.
- W2055803040 hasAuthorship W2055803040A5079969814 @default.
- W2055803040 hasConcept C121446783 @default.
- W2055803040 hasConcept C126322002 @default.
- W2055803040 hasConcept C134018914 @default.
- W2055803040 hasConcept C135343436 @default.
- W2055803040 hasConcept C176685330 @default.
- W2055803040 hasConcept C2778182776 @default.
- W2055803040 hasConcept C2778709874 @default.
- W2055803040 hasConcept C2988405389 @default.
- W2055803040 hasConcept C500499127 @default.
- W2055803040 hasConcept C71315377 @default.
- W2055803040 hasConcept C71924100 @default.
- W2055803040 hasConcept C86803240 @default.
- W2055803040 hasConceptScore W2055803040C121446783 @default.
- W2055803040 hasConceptScore W2055803040C126322002 @default.
- W2055803040 hasConceptScore W2055803040C134018914 @default.
- W2055803040 hasConceptScore W2055803040C135343436 @default.
- W2055803040 hasConceptScore W2055803040C176685330 @default.