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- W2055804951 abstract "Most cases of early onset familial Alzheimer's disease (FAD) involve mutations in presenilins (PS1 and PS2) genes. The C-terminal portion of PS2 is a homologue with an apoptosis-linked gene (ALG-3). To characterise the role of PS1 in apoptosis, we overexpressed the corresponding C-terminal fragment of PS1 (PS1-f) under the control of the tetracycline-responsive transactivator in Jurkat cells. The tight regulation of the expression of the 11 kDa PS1-f peptide was verified. A 50% inhibition of anti-Fas induced apoptosis was observed upon PS1-f transient overexpression compared to the repressed state. Stable transfectants selectively overexpressing PS1-f revealed a transient protective effect of 30% after apoptosis induction." @default.
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- W2055804951 date "1999-03-01" @default.
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- W2055804951 title "Overexpression of a C-terminal fragment of Presenilin 1 delays anti-Fas induced apoptosis in Jurkat cells" @default.
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- W2055804951 doi "https://doi.org/10.1016/s0304-3940(99)00097-x" @default.
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