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• W2055812629 abstract "Intrauterine undernutrition plays a role in the development of adult hypertension. Most studies are done in male offspring to delineate the mechanisms whereby blood pressure may be raised; however, the vascular mechanisms involved in female offspring are unclear. Female offspring of pregnant Sprague-Dawley rats fed either a control (C; 18%) or a low-protein (LP; 6%) diet during pregnancy were used. Birth weight and later growth were markedly lower in LP than in C offspring. LP offspring exhibited impaired estrous cyclicity with increased mean arterial pressure. Hypotensive response to acetylcholine (ACh) and the hypertensive response to phenylephrine (PE) were greater in LP than in C rats. N-nitro-<i>L</i>-arginine methyl ester (<i>L</i>-NAME) induced greater hypertensive responses in C than in LP rats. Endothelium-intact mesenteric arteries from LP offspring exhibited increased contractile responses to PE and reduced vasodilation in response to ACh. In endothelium-denuded arteries, relaxation responses to sodium nitroprusside were similar in both groups. Basal and ACh-induced increase in vascular nitrite/nitrate production was lower in LP than in C offspring. <i>L</i>-NAME or 1H-1,2,4-oxadiazolo-4,3-quinoxalin-1-one inhibited ACh relaxations and enhanced PE contractions in C offspring, but had minimal effect in LP rats. The decreasedNO-mediated vascular response might explainthe increased vascular contraction and arterial pressure infemale offspring with low birth weight." @default.
• W2055812629 created "2016-06-24" @default.
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• W2055812629 date "2008-10-30" @default.
• W2055812629 modified "2023-10-06" @default.
• W2055812629 title "Protein Restriction during Pregnancy Induces Hypertension and Impairs Endothelium-Dependent Vascular Function in Adult Female Offspring" @default.
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• W2055812629 doi "https://doi.org/10.1159/000166390" @default.
• W2055812629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2860528" @default.
• W2055812629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18957856" @default.
• W2055812629 hasPublicationYear "2008" @default.
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