Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055826631> ?p ?o ?g. }
- W2055826631 endingPage "L496" @default.
- W2055826631 startingPage "L488" @default.
- W2055826631 abstract "Occupational exposure to mineral dusts, such as silica, has been associated with progressive pulmonary inflammation, lung cancer, and fibrosis. However, the mechanisms involved in this process are poorly understood. Because p53 is a key transcription factor regulating many important apoptosis-related genes, we hypothesized that p53 may play a key role in silica-induced apoptosis and that abnormal regulation of p53 by silica may contribute to development of lung cancer as well as silicosis. We used both in vitro and in vivo studies to test this hypothesis. Treatment of JB6 cells carrying a p53-luciferase reporter plasmid with silica caused dose-dependent p53 transactivation. Western blot indicates that silica not only stimulated p53 protein expression but also caused p53 phosphorylation at Ser392. TUNEL and DNA fragmentation analysis show that silica caused apoptosis in both JB6 cells and wild-type p53 ( p53+/+) fibroblasts but not in p53-deficient ( p53−/−) fibroblasts. Similar results were obtained by in vivo studies. Intratracheal instillation of mice with silica induced apoptosis in the lung of p53+/+ mice, whereas this induction was significantly inhibited in p53−/− mice. Confocal image analysis indicates that most apoptotic cells induced by silica were alveolar macrophages. These results demonstrate for the first time that silica induces p53 transactivation via induction of p53 protein expression and phosphorylation of p53 protein and that p53 plays a crucial role in the signal transduction pathways of silica-induced apoptosis. This finding may provide an important link in understanding the molecular mechanisms of silica-induced carcinogenesis and pathogenesis in the lung." @default.
- W2055826631 created "2016-06-24" @default.
- W2055826631 creator A5006025102 @default.
- W2055826631 creator A5029072307 @default.
- W2055826631 creator A5054459491 @default.
- W2055826631 creator A5064780042 @default.
- W2055826631 creator A5080894648 @default.
- W2055826631 creator A5081679390 @default.
- W2055826631 creator A5086073951 @default.
- W2055826631 date "2005-03-01" @default.
- W2055826631 modified "2023-10-17" @default.
- W2055826631 title "Essential role of p53 in silica-induced apoptosis" @default.
- W2055826631 cites W1589415602 @default.
- W2055826631 cites W1680634601 @default.
- W2055826631 cites W1768877551 @default.
- W2055826631 cites W1842375597 @default.
- W2055826631 cites W1967051273 @default.
- W2055826631 cites W1969469693 @default.
- W2055826631 cites W1971928705 @default.
- W2055826631 cites W1977707442 @default.
- W2055826631 cites W1983505449 @default.
- W2055826631 cites W1987593522 @default.
- W2055826631 cites W1991494214 @default.
- W2055826631 cites W1993246806 @default.
- W2055826631 cites W2002503549 @default.
- W2055826631 cites W2005945508 @default.
- W2055826631 cites W2008301561 @default.
- W2055826631 cites W2013752620 @default.
- W2055826631 cites W2044117808 @default.
- W2055826631 cites W2044339054 @default.
- W2055826631 cites W2054694907 @default.
- W2055826631 cites W2055349083 @default.
- W2055826631 cites W2064508977 @default.
- W2055826631 cites W2071864660 @default.
- W2055826631 cites W2077561395 @default.
- W2055826631 cites W2078297328 @default.
- W2055826631 cites W2082847081 @default.
- W2055826631 cites W2086894586 @default.
- W2055826631 cites W2088172210 @default.
- W2055826631 cites W2106410559 @default.
- W2055826631 cites W2107665469 @default.
- W2055826631 cites W2115746022 @default.
- W2055826631 cites W2117765990 @default.
- W2055826631 cites W2124052729 @default.
- W2055826631 cites W2134858249 @default.
- W2055826631 cites W2138302361 @default.
- W2055826631 cites W2148200419 @default.
- W2055826631 cites W2151632264 @default.
- W2055826631 cites W2157099277 @default.
- W2055826631 cites W2167970895 @default.
- W2055826631 cites W4234801656 @default.
- W2055826631 doi "https://doi.org/10.1152/ajplung.00123.2003" @default.
- W2055826631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15557088" @default.
- W2055826631 hasPublicationYear "2005" @default.
- W2055826631 type Work @default.
- W2055826631 sameAs 2055826631 @default.
- W2055826631 citedByCount "46" @default.
- W2055826631 countsByYear W20558266312012 @default.
- W2055826631 countsByYear W20558266312013 @default.
- W2055826631 countsByYear W20558266312014 @default.
- W2055826631 countsByYear W20558266312015 @default.
- W2055826631 countsByYear W20558266312016 @default.
- W2055826631 countsByYear W20558266312017 @default.
- W2055826631 countsByYear W20558266312018 @default.
- W2055826631 countsByYear W20558266312019 @default.
- W2055826631 countsByYear W20558266312020 @default.
- W2055826631 countsByYear W20558266312021 @default.
- W2055826631 countsByYear W20558266312022 @default.
- W2055826631 countsByYear W20558266312023 @default.
- W2055826631 crossrefType "journal-article" @default.
- W2055826631 hasAuthorship W2055826631A5006025102 @default.
- W2055826631 hasAuthorship W2055826631A5029072307 @default.
- W2055826631 hasAuthorship W2055826631A5054459491 @default.
- W2055826631 hasAuthorship W2055826631A5064780042 @default.
- W2055826631 hasAuthorship W2055826631A5080894648 @default.
- W2055826631 hasAuthorship W2055826631A5081679390 @default.
- W2055826631 hasAuthorship W2055826631A5086073951 @default.
- W2055826631 hasConcept C104317684 @default.
- W2055826631 hasConcept C1292079 @default.
- W2055826631 hasConcept C142724271 @default.
- W2055826631 hasConcept C143425029 @default.
- W2055826631 hasConcept C150903083 @default.
- W2055826631 hasConcept C153911025 @default.
- W2055826631 hasConcept C185592680 @default.
- W2055826631 hasConcept C190283241 @default.
- W2055826631 hasConcept C196795494 @default.
- W2055826631 hasConcept C207001950 @default.
- W2055826631 hasConcept C2776415932 @default.
- W2055826631 hasConcept C2777811718 @default.
- W2055826631 hasConcept C502942594 @default.
- W2055826631 hasConcept C552990157 @default.
- W2055826631 hasConcept C55493867 @default.
- W2055826631 hasConcept C555283112 @default.
- W2055826631 hasConcept C62478195 @default.
- W2055826631 hasConcept C71924100 @default.
- W2055826631 hasConcept C86339819 @default.
- W2055826631 hasConcept C86803240 @default.
- W2055826631 hasConcept C95444343 @default.