FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055832844> ?p ?o ?g. }

• W2055832844 endingPage "17" @default.
• W2055832844 startingPage "1" @default.
• W2055832844 abstract "Recognition of apoptotic cells by macrophages is crucial for resolution of inflammation, immune tolerance, and tissue repair. Cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) and hepatocyte growth factor (HGF) play important roles in the tissue repair process. We investigated the characteristics of macrophage COX-2 and PGE2 expression mediated by apoptotic cells and then determined how macrophages exposed to apoptotic cells in vitro and in vivo orchestrate the interaction between COX-2/PGE2 and HGF signaling pathways. Exposure of RAW 264.7 cells and primary peritoneal macrophages to apoptotic cells resulted in induction of COX-2 and PGE2. The COX-2 inhibitor NS-398 suppressed apoptotic cell-induced PGE2 production. Both NS-398 and COX-2-siRNA, as well as the PGE2 receptor EP2 antagonist, blocked HGF expression in response to apoptotic cells. In addition, the HGF receptor antagonist suppressed increases in COX-2 and PGE2 induction. The in vivo relevance of the interaction between the COX-2/PGE2 and HGF pathways through a positive feedback loop was shown in cultured alveolar macrophages following in vivo exposure of bleomycin-stimulated lungs to apoptotic cells. Our results demonstrate that upregulation of the COX-2/PGE2 and HGF in macrophages following exposure to apoptotic cells represents a mechanism for mediating the anti-inflammatory and antifibrotic consequences of apoptotic cell recognition." @default.
• W2055832844 created "2016-06-24" @default.
• W2055832844 creator A5001570418 @default.
• W2055832844 creator A5025141436 @default.
• W2055832844 creator A5030740700 @default.
• W2055832844 creator A5057580619 @default.
• W2055832844 creator A5068693487 @default.
• W2055832844 creator A5080683028 @default.
• W2055832844 date "2014-01-01" @default.
• W2055832844 modified "2023-09-26" @default.
• W2055832844 title "Interaction of Apoptotic Cells with Macrophages Upregulates COX-2/PGE₂and HGF Expression via a Positive Feedback Loop" @default.
• W2055832844 cites W1525044292 @default.
• W2055832844 cites W1530081569 @default.
• W2055832844 cites W1969176034 @default.
• W2055832844 cites W1977273234 @default.
• W2055832844 cites W1980146613 @default.
• W2055832844 cites W1983072435 @default.
• W2055832844 cites W1985496701 @default.
• W2055832844 cites W1989819959 @default.
• W2055832844 cites W1995721099 @default.
• W2055832844 cites W2002469066 @default.
• W2055832844 cites W2027481680 @default.
• W2055832844 cites W2033764325 @default.
• W2055832844 cites W2043981736 @default.
• W2055832844 cites W2045152291 @default.
• W2055832844 cites W2045770017 @default.
• W2055832844 cites W2046459498 @default.
• W2055832844 cites W2052534316 @default.
• W2055832844 cites W2063332426 @default.
• W2055832844 cites W2067490052 @default.
• W2055832844 cites W2081603767 @default.
• W2055832844 cites W2095537212 @default.
• W2055832844 cites W2106379906 @default.
• W2055832844 cites W2127849402 @default.
• W2055832844 cites W2137086978 @default.
• W2055832844 cites W2149072783 @default.
• W2055832844 cites W2151014103 @default.
• W2055832844 doi "https://doi.org/10.1155/2014/463524" @default.
• W2055832844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4052493" @default.
• W2055832844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24959005" @default.
• W2055832844 hasPublicationYear "2014" @default.
• W2055832844 type Work @default.
• W2055832844 sameAs 2055832844 @default.
• W2055832844 citedByCount "12" @default.
• W2055832844 countsByYear W20558328442016 @default.
• W2055832844 countsByYear W20558328442017 @default.
• W2055832844 countsByYear W20558328442018 @default.
• W2055832844 countsByYear W20558328442019 @default.
• W2055832844 countsByYear W20558328442020 @default.
• W2055832844 countsByYear W20558328442022 @default.
• W2055832844 countsByYear W20558328442023 @default.
• W2055832844 crossrefType "journal-article" @default.
• W2055832844 hasAuthorship W2055832844A5001570418 @default.
• W2055832844 hasAuthorship W2055832844A5025141436 @default.
• W2055832844 hasAuthorship W2055832844A5030740700 @default.
• W2055832844 hasAuthorship W2055832844A5057580619 @default.
• W2055832844 hasAuthorship W2055832844A5068693487 @default.
• W2055832844 hasAuthorship W2055832844A5080683028 @default.
• W2055832844 hasBestOaLocation W20558328441 @default.
• W2055832844 hasConcept C104317684 @default.
• W2055832844 hasConcept C127561419 @default.
• W2055832844 hasConcept C134018914 @default.
• W2055832844 hasConcept C150903083 @default.
• W2055832844 hasConcept C170493617 @default.
• W2055832844 hasConcept C185592680 @default.
• W2055832844 hasConcept C190283241 @default.
• W2055832844 hasConcept C203014093 @default.
• W2055832844 hasConcept C207001950 @default.
• W2055832844 hasConcept C2776914184 @default.
• W2055832844 hasConcept C2776996007 @default.
• W2055832844 hasConcept C2777198256 @default.
• W2055832844 hasConcept C2777956040 @default.
• W2055832844 hasConcept C502942594 @default.
• W2055832844 hasConcept C55493867 @default.
• W2055832844 hasConcept C86803240 @default.
• W2055832844 hasConcept C95444343 @default.
• W2055832844 hasConceptScore W2055832844C104317684 @default.
• W2055832844 hasConceptScore W2055832844C127561419 @default.
• W2055832844 hasConceptScore W2055832844C134018914 @default.
• W2055832844 hasConceptScore W2055832844C150903083 @default.
• W2055832844 hasConceptScore W2055832844C170493617 @default.
• W2055832844 hasConceptScore W2055832844C185592680 @default.
• W2055832844 hasConceptScore W2055832844C190283241 @default.
• W2055832844 hasConceptScore W2055832844C203014093 @default.
• W2055832844 hasConceptScore W2055832844C207001950 @default.
• W2055832844 hasConceptScore W2055832844C2776914184 @default.
• W2055832844 hasConceptScore W2055832844C2776996007 @default.
• W2055832844 hasConceptScore W2055832844C2777198256 @default.
• W2055832844 hasConceptScore W2055832844C2777956040 @default.
• W2055832844 hasConceptScore W2055832844C502942594 @default.
• W2055832844 hasConceptScore W2055832844C55493867 @default.
• W2055832844 hasConceptScore W2055832844C86803240 @default.
• W2055832844 hasConceptScore W2055832844C95444343 @default.
• W2055832844 hasFunder F4320322120 @default.
• W2055832844 hasLocation W20558328441 @default.
• W2055832844 hasLocation W20558328442 @default.
• W2055832844 hasLocation W20558328443 @default.
• W2055832844 hasLocation W20558328444 @default.

• next