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- W205584776 abstract "Advances in molecular technologies challenge the different concepts of causality in biology, epidemiology and multistage mathematical models. The lack of integration of the different aspects of causality into a common framework could postpone our attempts to build a human causal model of carcinogenesis. We present here some aspects of differences in methodology, terminology and traditions between the scientific disciplines and propose a research strategy using functional analyses of the transcriptome and epigenetics to illuminate causality in complex biological systems. Overcoming the challenges of biological material collection suitable for such analyses into a prospective design, this could give unique opportunities for verification of mechanistic information from basic biological research in a human model system. The ultimate goal is to obtain a dynamic causal description of the different carcinogenesis stages. The success of this novel approach depends on the biological relationship between the gene expression of the somatic driver mutations or co-expressed genes in tumours and the gene expressions mirrored in peripheral blood along the different stages of carcinogenesis. The use of gene expression profiles and epigenetics could produce a functional concept of causality to explain the human multistage carcinogenic process." @default.
- W205584776 created "2016-06-24" @default.
- W205584776 creator A5067257359 @default.
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- W205584776 date "2010-03-15" @default.
- W205584776 modified "2023-09-26" @default.
- W205584776 title "Towards a more functional concept of causality in cancer research." @default.
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- W205584776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3076760" @default.
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